Pascal Soriot: Thank you, Dave. Emily Field, Barclays. Emily, go ahead.
Emily Field: Hi, thanks for taking my questions. I just have two. The first one, just on Lynparza and maybe digging in a little bit more to the dynamics going on in ovarian, how much of sales is second-line ovarian? And just kind of were aware of the registration being pulled for the competitor asset, but sort of why is this impact leading over into Lynparza, do you expect to return to growth in the US for this asset? And then just a question on the raised guidance for China. I was just wondering, is this truly based on sort of improving demand in the region. Is this impacted in any way by some of the price adjustments that are happening with the product from the NRDL, just any incremental color you can give there? Thank you.
Pascal Soriot: Dave, do you want to cover the first one and Leon could cover the second one?
David Fredrickson: Yes. Emily, thanks for the question. So, first part of this is that if we take a look at PARP class starts across lines in ovarian cancer. Over the course of the year, the starts are declining, and that is predominantly a phenomena of lower desire on the part of medical oncologists to treat in the second line setting in ovarian cancer as there’s been, as you know, I think, quite a lot of changes that have been happening there with respect to competitor labels and discussion and dialogue with the FDA. Within the context of that, we’ve been doing a good job to continue to drive our Pala and solo indications. Solo, we really have probably fully penetrated though there is opportunity to continue to drive HRD testing rates in the front line.
Unfortunately, a bit of what’s happening is that those gains are being offset by some of the second line declines. Now, today, in terms of where we stand, the second line represents a significant minority of our ovarian cancer business. And so I’m hopeful that even with a narrower PROPEL label, that we have an opportunity to continue to drive growth in Lynparza with PROPEL and some of the other populations that I’ve mentioned, but it is going to be slower progress that we’re making. I will say, outside of the United States and Europe, we’re making nice progress with PROPEL within Germany. We’re continuing to drive growth opportunities that we have in breast cancer and also within ovarian cancer ex-US, but I think that the growth rates that we’ll see on Lynparza, while still in front of us, will be a bit slower.
I do, though, look forward with optimism to hopefully having a regulatory path forward with DOE. We’ll see how things net with DOO and those would certainly be enthusiastic areas for us to launch into.
Leon Wang: Yes. Regarding China guidance, I think China is — this year is — we have some headwinds on oncology price cuts because of NRDL renewed last year, major oncology products get a cut. And also silicon getting to VVP, which is a large product. But actually, we should also focus on a lot of opportunities because we’re launching rare disease and also Enhertu in China, [Indiscernible] in China. So a lot of new products are being launching a little bit lagging behind the global pace, but I think we are looking forward to a lot of new launches. We haven’t yet launched Imfinzi, Topaz and also Himalaya. And we also have launching strongly into dollar indication and the FLAURA 2. And for inflation business, Symbicort is a very strong growth and [Indiscernible] second year now.
