Scott Burrows: Certainly, I think there’s an opportunity for growth in the market from a couple of aspects. The first one is, if you look at the epidemiology, there are clearly a lot of patients who are not currently on prescription treatment. And that may be a variety of reasons, lack of insurance coverage, but we know that one of those factors is frustration with existing treatment choices and so having a product like ZORYVE out there that is efficacious is safe and well tolerated and is readily available, may bring some of those patients back off of their couches and back into the dermatologist office. I think the other thing is that topical steroids are very effective in treating plaque psoriasis, but they can’t really be used chronically safely.
And so there’s a natural limit on consumption of topical steroids and the non-steroid alternatives historically have not been very effective, nor have they been very well tolerated. So having a drug that’s as efficacious and is safe and more tolerated as there, there may be some opportunity for volume growth even amongst existing patients based on that as well. I think — sorry, I think the other point I would make, too, is that outside of psoriasis, I think as we add these additional indications as well, those are further opportunities to grow the overall opportunity for nonsteroidals. Ken, do you have any additional thoughts or Patrick
Ken Lock: Pat.
Patrick Burnett: No.
Eric McIntyre: Olivia, can we move to the next question?
Frank Watanabe: Thanks, Greg.
Operator: Our next question coming from the line of Louise Chen with Cantor. Your line is open.
Louise Chen: Hi. Thank you for taking my questions here. So first question I have for you is, how do you think the uptake for atopic dermatitis, if approved, will be compared to what you see for psoriasis and why? And then secondly, what do you think the read-through is from the adult psoriasis data — sorry, the adult AD data to the pediatric AD data? How should we think about that? And then last question is just thinking about the potential competitive advantages of ARQ-234 and where that might enter the clinic? Thank you.
Frank Watanabe: So I’m going to take the first one, and then I’ll ask Patrick to talk about the 80 read-through and the 234 question. So I think that with regard to uptake, I think there certainly is a potential that atopic dermatitis could have a faster uptake for a couple of reasons. The first one is, as Ken mentioned, there could be some acceleration in access decisions for atopic dermatitis just based on psoriasis. The second one is, we have the advantage that doctors are going to have a great deal of familiarity with topical roflumilast when we get the approval in atopic dermatitis. And I think that’s particularly important because we know that when we launched ZORYVE, there was a certain degree of skepticism about topical PDE4s based on prior experience with the other topical PDE4 inhibitor, and it’s taken doctors a little while to dispel some of those anxieties.
None of that will be an obstacle to the adoption in atopic dermatitis. So I think when you pull all of those together, we certainly could see a faster initial uptake in atopic dermatitis. Ken, any other thoughts from your side?
Ken Lock: And then so Patrick, can you maybe talk about the read-through from INTEGUMENT-1 and 2 to INTEGUMENT-PED and then ARQ-234 and some of its advantages in the clinic? Clinical advantages.
