William Collier: Yes. So on the update, we’ve said we’ll provide an update in the first half of the year. And obviously, as we continue to progress during the year, if there’s further news, then we’ll provide further updates. I am actually having to work from home today. You can tell I have a pretty horrendous head cold. I actually don’t have the data for the number of weeks of therapy in front of me. So I just wonder if there’s anyone else on the call who has that information. I don’t know whether Mike, or Mike Sofia. I’m also just looking back on the deck here.
Michael Sofia: Yes, give me one second, Bill. So patients have been off therapy — as of the last data update at least, patients have been off therapy anywhere from sort of, let’s see, to call it, roughly 20 weeks to 44 weeks or more. So as of the last data update, remember. So patients, obviously, can continue to track that forward and get a sense for where patients are.
William Collier: Yes. That is Slide 13, actually in the corporate deck, which you can see the data for the nine patients. And this was what we reported in December last year. So Mike has given you the range of weeks there. And then we can add on, I guess, a few more weeks since the December update last year.
Thomas Yip: Right. Yes, yes. As you alluded to, seven patients a month in mind. So it’s been a couple of months, so expecting more than 44 weeks as opposed. And then as you — as we continue to see this off treatment data with more patients, what do you expect some findings that you continue to collect that could impact the ongoing Phase II combination studies?
William Collier: You mean what data could we expect from these remaining seven patients?
Thomas Yip: More specifically, what kind of findings do you expect from these patients that could potentially change or alter any of the Phase II combination studies that are either ongoing or new cohorts?
William Collier: Yes. Okay, understood. Well, I mean, obviously, we want to continue to track them. I hope that there are not too many more that meet the criteria to restart treatment, but that’s one potential outcome. Another potential outcome is we potentially get a few who do actually go undetectable. We just have to track. And obviously, we’ll report if that does happen. And then the other outcome is that actually they kind of continue to stay as they are, which is low levels of HBV DNA, low levels of surface antigen, not meeting the criteria to restart treatment. But not undetectable, which I think would be a demonstration that actually treatment with 729 and the NUC does actually get these patients to a position where they’re able to come off therapy.
Now it might also indicate that the ultimate combination, the functional cure would be 729 and NUC, and then a third agent designed to further boost the immune system, which is why our PD-L1 program comes in. So that, I think, would be the interesting information. And then obviously, we’re looking for the same thing in our Phase IIa studies, whether or not the addition of interferon and/or VTP-300 plus or minus Nivo, results in further s-antigen reductions than 729 alone. And then obviously, in the follow-up period, we’ll be looking to see how these patients respond when they are off treatment.
Thomas Yip: Got it. Thank you so much. Perhaps one final question from us. Speaking of the VTP-300 combination study, what type of preliminary data should we expect to be announced in the second half of this year from this study?
