Bob Bradway: I know a number of you have submitted questions, so we’re continuing to work through the list. Anybody who hasn’t yet shot Arvind an e-mail, we’re going to go through those and we’ve got couple of handfuls still to go. So let’s, Arvind, go to the next question.
Arvind Sood: Yes. The next 1 is a question by Greg Renza of RBC Capital Markets and Dave, this is for you. We were interested in hearing some color on the antibody drug conjugate strategy in light of the recent deals. How is the team approaching the space?
David Reese: Yes. Thanks, Greg. What I view this is as another modality in our toolkit. We’ve been watching the antibody drug conjugate technology quite closely for the past several years. It’s advanced, so what we feel is that we’ll use ADCs on appropriate targets. I view it as an addition and an extension of our modalities. These collaborations bring together our experience on target identification and validation as well as, of course, antibody generation with some of the newer conjugation technology. So as that progresses, more to come but you should view this as additive to our armamentarium.
Arvind Sood: Okay. The next question is by Tim Anderson of Wolfe Research. And his question is on AMGEVITA in the U.S. And he’s asking, any commentary and your comfort with sell-side consensus for U.S. sales which seems to be around $600 million in 2023? And anything you can say about contract specifics such as whether there’s price protection, if any of them go beyond 2023?
Murdo Gordon: Yes, we don’t give product-specific guidance. And this is a new event in the U.S. biosimilar market, given this is the first big pharmacy benefit product to go up. So we will continue to update all of you as the launch progresses. We have said we think this will be gradually slope on this launch and I’m going have to keep you apprised as we go forward.
Arvind Sood: Okay. The next 1 is by Dave Risinger of SVB Securities and he has 2 questions. The first 1 is for you, Dave. Please discuss key novel drug candidate readouts to watch in 2023. And the second 1 for you, Murdo. How do you expect formulary positioning for AMGEVITA to potentially change in January of 2024 after AMGEVITA is assigned an interchangeability designation?
David Reese: Yes. Thanks, David. This is a year where certainly my focus, my team’s focus will be on execution, a huge amount to carry forward in the pipeline. So things that I would keep an eye on, how well are we enrolling the Phase III Olpasiran trial? How well are we enrolling the AMG 133 Phase II trial? In the general medicine portfolio, in inflammation, how are the suite of rocatinlumab trials enrolling? How are we delivering on TEZSPIRE additional indications? And then finally, in oncology, things to keep an eye on are the tarlatumab program, not only the Phase II potentially registrational trial readout in the second half of the year but also initiation of a Phase III trial in second-line disease. These are some of the top line things that I’ll be paying attention to. And then there are, of course, a host of others earlier in the pipeline and in discovery research.
Murdo Gordon: And just on the AMGEVITA question, I would say that we have a commitment to continuing to make sure that the product attributes of our biosimilars provide payers, providers and patients with all of the benefits that they’re looking for. And we’re also trying to ensure that there is no reason to switch away from AMGEVITA in the long range. So we hope that interchangeability, the high concentration and the fact that we already have a citrate-free product on the market, along with the services we provide, along with the fact that this is an Amgen team of people who understand the inflammation indications of this product very well and they have relationships with the customers that prescribe HUMIRA, we feel really good about the durability of AMGEVITA long term beyond 2024.
