David Reese: Yes. In terms of the filing time lines, once we have the data in hand, we’ll be then giving guidance as to when we expect filing and potential approval of that after the appropriate regulatory interactions. It’s important, I think, as Bob were put this in context, let me ask Murdo to comment here.
Murdo Gordon: Yes. Thanks, Dave. We have had some inbound questions on this, as you can imagine, during the day, given that we are launching. So far, launch is progressing well. We have product making its way into the channel and we’re already receiving inbound interest in AMGEVITA from payers, prescribers and patients. One thing that’s important to remember is the current product that we have in the market is a lower concentration, original concentration AMGEVITA or adalimumab but it is citrate-free, meaning that the patient experience here is still 1 where we minimize the injection site pain by having a citrate-free formulation. And patient experience here has been positive in our clinical trials and we anticipate that not having a high concentration will not be a barrier in the market.
These are very low volumes that are injected through an auto-injectable pen. And we’ve seen very, very good reliability of patients being able to administer. In addition, of course, we provide nurse support for patients. And then while it wasn’t asked, I think it’s also important to note that we are providing financial assistance, support and reimbursement support for both prescribers and patients as we launch the product. So really a full suite of services and support that you would expect for a branded launch being applied to the launch of the first biosimilar, adalimumab, to launch in the U.S., that is AMGEVITA.
Bob Bradway: Okay. Thank you, Murdo and Dave. Let’s go to the next question, Arvind.
Arvind Sood: So the next question is from Geoff Meacham from BofA Merrill Lynch. And his question is, he said, I know you have AMGEVITA but are you expecting an indirect impact in the second half of ’23 or the first half of ’24 from all the HUMIRA biosimilars and STELARA, on Otezla and ENBREL mainly? And he is interested in the volume and price impact.
Bob Bradway: Okay. Murdo, you want to share your thoughts on that?
Murdo Gordon: It’s hard for me, obviously, to comment on what competitors may do as other biosimilars of adalimumab enter the market beyond July. But what we have seen coming into 2023 is a good cycle of reimbursement negotiations and we’ve been able to secure a very broad coverage for both ENBREL and Otezla. We expect that insurance coverage to continue throughout the course of 2023. And as is usual, we had small concessions on net price to secure that broad reimbursement but nothing unusual compared to prior years.
Arvind Sood: The next question is from Chris Raymond from Piper Sandler. And he has 2 questions. The first 1 is on Otezla. And Chris says, I know there are a lot of puts and takes on this market and I know you guys have highlighted a tailwind of mild-to-moderate psoriasis patients coming into therapy. But Otezla is kind of unique in that there is a sizable discontinuation rate. Just with that, if you’re probably not going away, talk about why we shouldn’t be more concerned about and maybe just as importantly, the next-generation molecules that are coming behind it. Especially noticing that a decline Q-over-Q both in the U.S. and rest of the world, even with a 9% inventory build, any color on how you grow through this coming competition would be very helpful. And then he has a question on AMGEVITA.
