Affimed N.V. (AFMD): OrbiMed Advisors Cuts Its Position

Page 7 of 12 – SEC Filing

(c)

Seller	Date of Transaction	Transaction	Number of Shares		Price Per Share*
OPI III	August 26, 2016	Sold	13,022		$2.56
Associates III	August 26, 2016	Sold	122		$2.56
OPI III	August 29, 2016	Sold	3,922		$2.61
Associates III	August 29, 2016	Sold	37		$2.61
OPI III	August 30, 2016	Sold	2,870		$2.56
Associates III	August 30, 2016	Sold	27		$2.56
OPI III	August 31, 2016	Sold	892		$2.51
Associates III	August 31, 2016	Sold	8		$2.51
OPI III	September 1, 2016	Sold	2,576		$2.52
Associates III	September 1, 2016	Sold	24		$2.52
OPI III	September 2, 2016	Sold	5,845		$2.53
Associates III	September 2, 2016	Sold	55		$2.53
OPI III	September 6, 2016	Sold	10,303		$2.61
Associates III	September 6, 2016	Sold	97		$2.61
OPI III	September 7, 2016	Sold	10,105		$2.78
Associates III	September 7, 2016	Sold	95		$2.78
OPI III	September 22, 2016	Sold	346,400		$2.90
Associates III	September 22, 2016	Sold	3,600		$2.90

___________________________

*The Price Per Share reported above is a weighted average price.  The Shares were sold in multiple transactions at prices ranging from:  $2.55 to $2.59 (August 26, 2016); $2.60 to $2.64 (August 29, 2016); $2.55 to $2.60 (August 30, 2016); $2.50 to $2.52 (August 31, 2016); $2.51 to $2.56 (September 1, 2016); $2.51 to $2.56 (September 2, 2016); $2.60 to $2.65 (September 6, 2016); $2.62 to $3.03 (September 7, 2016); and $2.90 to $3.11 (September 22, 2016).  Upon request, the Reporting Persons undertake to provide the Issuer, any security holder of the Issuer, or the SEC full information regarding the Shares purchased at each separate price within the ranges set forth above.

Except as disclosed above, the Reporting Persons have not effected any transactions in the Shares during the past sixty (60) days.

(d)	Not applicable.

(e)	Not applicable.

Item 6.  Contracts, Arrangements, Understandings or Relationship with Respect to Securities of the Issuer

In addition to the relationships between the Reporting Persons described in Items 2, 3 and 5 above, GP III is the sole general partner of OPI III, pursuant to the terms of the limited partnership agreement of OPI III.  Advisors is the sole managing member of GP III, pursuant to the terms of the limited liability company agreement of GP III, and the sole general partner of Associates III, pursuant to the terms of the limited partnership agreement of Associates III.  Pursuant to these agreements and relationships, Advisors and GP III have discretionary investment management authority with respect to the assets of OPI III, and Advisors has discretionary investment management authority with respect to the assets of Associates III.  Such authority includes the power of GP III and Advisors to vote and otherwise dispose of securities purchased by OPI III, and the power of Advisors to vote and otherwise dispose of securities purchased by Associates III.  The number of outstanding Shares held of record by OPI III is 3,343,965, and the number of outstanding Shares held of record by Associates III is 31,035.  Advisors and Isaly may be considered to hold indirectly 3,375,000 Shares, and GP III may be considered to hold indirectly 3,343,965 Shares.

On June 29, 2015, Michael B. Sheffery, a Partner Emeritus of Advisors, retired from the board of directors of the Issuer at the expiration of his term.