Mohamed Zaki: If I may ask, Kristen, also regarding the [indiscernible] story, is that we need to see how the control arm in the trial actually did to be able to better evaluate the data and understand it better. Specifically, this is in third line plus, if I understand the trial correctly. Our target is for LOTIS-5 and the potential to see this to go to second line plus. So it’s not directly, but in a very minimal number of patients. And when you get to third or fourth line, there may be some combo. However, we don’t know that in details, of course, to be able to understand it better.
Gregory Renza: Ameet, maybe just a follow up as Patrick has discussed the NextGen platform. Just wondering – and we all look forward to an event later this year, as you mentioned. Just wonder if you could elaborate a bit on just the rationale for selecting NaPi2b, Claudin, and PSMA just for the NextGen ADCs. And do you have a sense at this point which targets or target has the strongest rationale for internal versus the external partnerships that Pepe alluded to?
Ameet Mallik: Maybe, Patrick, do you want to take the first part of the question? And then, Pepe, you can take the second part of the question around partnering.
Patrick van Berkel: We have selected these targets because we think that they fulfill all the criteria for good ADC targets. If you look at what’s known for them, it’s clear that for each and every target, there’s a very good level of validation for targeted approach. Of course, they’re all expressed in indications with high unmet need. And we also very carefully looked at the competitive landscape for NaPi2b, Claudin-6, PSMA and the undisclosed targets. And we believe that, in most cases, if not all, we’re among the first three to four players studying those targets. But, of course, with a differentiated approach using our novel exatecan-based platform. So to us, that means they really are attractive targets to work on.
Jose Carmona: Let me take the partners discussion. So as we disclosed, the next generation exatecan-based payload and the target earlier this year in January 4th, we did an outreach with several companies and we already started some discussions. These conversations and that potential partnership takes a few quarters. So it’s not something that you would do in a short turnaround. But we do see the interest and we will continue to advance those conversations for potential partnerships this year.
Operator: [Operator Instructions]. Our next question comes from the line of Kelly Shi with Jefferies.
Unidentified Participant: This is [indiscernible] for Kelly. First question, just wanted to confirm that – is safety the only thing that you need to clear before moving into second line? And when would you expect to have any data available from second line patient? Secondly, for AXL study, can you remind us if you enroll patient based on expression and we have that biomarker data available when the data is presented at AACR?
Mohamed Zaki: Yes, in terms of the expectation from LOTIS-7 dose escalation is to clear the dose levels. And based on that, [indiscernible] protocol, we are allowed to move directly to second line for expansion. We’re expecting to share information focused on safety in the second quarter and more on the expansion of second line in DLBCL specifically in later in 2024. In terms of AXL, so far our enrollment is not with a pre-selection strategy. However, as of the pancreatic enrollment will be enrichment and for non-small cell lung cancer we will be pre-selecting.
Operator: At this time, I’m showing no further questions. I’d like to hand the conference back over to Mr. Mallik for closing remarks.
Mohamed Zaki: Yeah, thanks all for your attention and interest in ADC Therapeutics. Between now and our next earnings call, we expect to share some important updates on LOTIS-7, on the futility analysis and top line data of ZYNLONTA as a single agent in marginal zone lymphoma, and on data being presented at AACR which we will follow up with a research investor event. As such, we look forward to multiple interactions with you in the coming months. With that, I would like to close the call. Thank you all.
Operator: This concludes today’s conference call. Thank you for your participation. You may now disconnect. Everyone, have a wonderful day.
