Mohamed Zaki: We’re actually have multiple agents in combination, including polatuzumab, glut and mocituzumab. We are trying to be the drug of choice in combination with or bispecific, not to mention also that we have a collaboration with IGM with their bispecific. So pretty much we’re combining with all bispecifics to be a backbone, whoever any of them gets approved and become in the landscape, we’d be able to combine with. I hope that’s answered your question.
Ameet Mallik: Yes. And in terms of lines of therapy, I mean, I think it will be an earlier amount of therapy. Particularly second line, I think there’s an opportunity to really change the landscape. And particularly if the combination works in a way that has a manageable side effect profile and lead to even better outcomes, deeper responses and more durable responses, you can imagine is starting to change and expand the opportunity for targeted therapy combinations in that second-line setting.
Unidentified Analyst: Great. Thank you, very much.
Operator: Our next question comes from Brian Cheng with JPMorgan. Please go ahead.
Brian Cheng: Thank you for taking my question. My first question is for Kristen. What was the split of academic versus community used in the last quarter for ZYNLONTA. And as you emphasize that community market’s where you see a lot of growth, near term, how long do you think that it will take you to get more traction there? And how do you think about just the changes with bispecific coming in? And I have a follow-up. Thank you.
Kristen Harrington-Smith: Okay. So, in terms of the split of academic versus community youth, it’s roughly 50-50. We just started to see — as we said, the penetration in the community is consistently growing. And we’ve just started to match the use from an academic perspective in terms of volume. Your second question was how long — to penetrate the community. They are — what we see is community treaters are generally slower to adopt new therapies for most new oncology launches, it probably takes about four to five years to really start to hit a peak market share. But what we do see for communities is community treaters is that because they’re slower to adopt it could take longer in that setting. But we will continue to chip away since we’re at about 35%. Our goal is to really match what we’re seeing in the academic setting.
Ameet Mallik: And I’d also add, Brian, that there’s a long tail. So, there’s a lot of fragmentation in the community centers. A lot of community doctors are seeing a patient every few months. But they also tend to be a lot stickier. So behavior changes works both ways. It’s takes longer to adopt, but we see is the accounts that are adopting are repeating and sticking with the product. And so — and we keep growing penetration month-over-month. So, I think as that happens, this is a great opportunity, and that’s a place where you had asked about bispecifics, and I’ll let Kristen comment further. Bispecifics are going to have a much more challenging time, we believe, in the community initially just given the safety profile. In the academic spending, where we’ve penetrated about 80% of accounts there’s still room for death, we think, even with bispecifics. But I’ll let Kristen comment on the bispecific point.
Kristen Harrington-Smith: Sure. I don’t have much else to add to that, but we just — we see the safety profile of bispecifics being one where the initial uptake will be in the academic setting. CRS, ICANS those are not adverse events that the community generally accustomed to treating right now. That’s why CAR Ts are reserved for the academic setting. So, we feel it will take time. And again, that is where we have our greatest opportunity right now to grow ZYNLONTA.
Unidentified Analyst: Great. And then looking at your LOTIS 5 in second line in combo wit rituxan, do you have a sense of when we could see the data from that study? And can you remind us whether there is an interim analysis built into this trial?
