Steven Mah: Okay. Great. And if I can just have one more. Has there been any changes to the timing of the GMP biologics manufacturing facility? And then also, as you start building out that downstream capability, is that impacting your partnership discussions? And again, I asked because I wanted to — just curious to know if maybe the Prelude collaboration was helped by the GMP biologics manufacturing capabilities that you’re building in?
Andrew Booth : Yes, I’ll take the first part of that question, Steve, it’s Andrew here. So we continue to invest in both the CMC and GMP manufacturing. I think our plan is to have the first sort of pilot batches and engineering batches for CMC development happening in 2024. So that will be next year. And the first — the engineering batches, qualification batches of the production facility would be in 2025. And those — that is also when the first batches from the facility that would ultimately go to support of Phase I. That does mean that the discovery on the programs that we’re starting today could be advanced through our own CMC cell line development and then GMP manufacturing capabilities. And I think that is of interest to partners, but I’ll maybe let Carl comment a little bit more on that.
Carl Hansen: Yes. Not too much to add except that we have a variety of discussions, particularly in the space of new venture creation or early companies, obviously, that are not equipped with manufacturing capabilities internally, where the integration of the front-end discovery, lead optimization, translational science, CMC, GMP altogether is a very attractive part of working with AbCellera. It provides a way to substantially shrink the time in going from an idea through to the start of clinical development. And frankly, release a huge amount of hassle that exists, particularly for smaller firms when they’re having to set up CDMO networks and relationships and manage that and jockey with the bigger firms to make sure that their programs are coming in, in the right slots and with some flexibility.
So we see it as a very important strategic advantage, that’s why we’re investing in it. It’s a heavy lift to put it together, but we’re crossing that right now and are confident that we’ll have that in place in 2025, as Andrew said.
Operator: The next question will be from the line of Malcolm Hoffman with BML.
Malcolm Hoffman: Malcolm on for Evan. I wanted to first ask about ABCL575. It’s noted that the molecule has been designed with greater potency and PK to enable less frequent dosing than benchmark molecules. Are you able to provide more color on what those benchmark molecules are. Are they the approved assets or other in development molecules from AbCellera?
Carl Hansen: Sure. So to be clear, what I said is that it’s been engineered and selected to have a combination of potency, PK and developability, particularly meaning high concentration formulations that we believe would allow it to be dosed less frequently than existing benchmark molecules. We are, of course, testing the ones that are disclosed out there. Amongst them are the clinical assets, including the one I mentioned earlier.
Operator: Thank you. At this time, there are no additional questions registered in the queue, so I will turn the call back over to Carl for final remarks.
Carl Hansen : Thank you, everyone, for joining the call today. This remains an exciting time for AbCellera with two big milestones in advancing our development candidates forward. We look forward to keeping you updated on future calls, and wish you well.
Operator: That concludes today’s conference call. Thank you all for your participation, and you may now disconnect your lines.
