Loretta Itri: Hi, Boris. It’s Loretta. We are seeing — it probably wouldn’t surprise you, what we’re seeing. We’re seeing the most patients from the most common tumors. And what I can tell you is the GYN tumors as a group, ovarian, endometrial, are one larger subset. Bladder, which is urinary bladder, which would not be surprising because it’s the one where we see the highest number of mutations in TSC1 is also a player. We see a smattering of sarcomas, but sarcomas are interesting. We have a small group of leiomyosarcomas. And then we see osteo, one of everything. So I would say that as a group, we see — the largest focus is GYN, but not specifically endometrial, as you suggested, but different types of GYN tumors mixed in.
We also see a fair number of GI tumors, pancreas, gall bladder, hepatocellular. That’s another fairly large portion of tumors. So I would say that we pretty much follow — we’re now seeing lung as well. In the beginning, we didn’t see much lung. Lung is now starting to come up as one of the more common types. So I think what we can say is that we are following the usual pattern of commonly observed tumors. Does that help?
Boris Peaker : Yes. Thank you very much for that lengthy answer. Thanks for taking my questions.
Operator: And one moment for our next question. Our next question will be coming from Roger Song. Roger, your line is open.
Roger Song: Great. Thanks for taking the question, and congrats for the progress. The first question may be related to the expansion strategy. Seemingly, you’re moving towards the — some of the validation from prior mTOR inhibitor, maybe histology-based trial like, Loretta, you say more traditional trial. Just curious if anything you will continue for FYARRO for the precision oncology route? Like any specific mutation or genetic mutation beyond the TSC1 and 2 may be suitable for FYARRO?
Loretta Itri: Roger, thank you. That’s a really interesting question. I think that we will take direction. As you know, one of the exploratory analysis that we will perform on the PRECISION trial is to look at co-mutations. At the moment, the only other targeted therapy that we are combining with, of course, is the Mirati compound, and there are data to suggest that those two mutation targets seem to work well. And I think that looking forward, we would have a very rich data set from PRECISION 1 to help us identify other potentially important co-mutations that contribute to efficacy. So I think right now, the answer would be no. But future forward, I think we will be opportunistic and follow the data.
Roger Song: Yes, that makes sense. Maybe just a quick follow-up. I understand the mutation, maybe you’re looking for some co-mutation. And any other biomarker strategy you will potentially to implement even in those traditional histology-based trial, maybe more better for FYARRO? Thank you.
Loretta Itri: At the very — at this very moment, I think we’ve kind of got a full plate. So I don’t think we would be taking on an additional study. But we continue to look very aggressively at other combinations, both precision medicine and standard chemotherapy, immunotherapy. We are always looking for opportunities to expand the potential of our compound.
