6. Palmdale
Population: 158,279
Located in Antelope Valley, Palmdale sits right on top of San Andreas Fault Line. One of the centers of the US aerospace industry could face utter destruction in case of a major earthquake in the area. Thousands of Palmdale residents who work in Los Angeles would be cut off from their families and homes. Several important regional railways running through Palmdale would be severed. More importantly, California Aqueduct that supplies a large portion of Los Angeles basin with water could also be cut. Good news for citizens of Palmdale is that city building code has been very strict in applying measures designed to prevent extensive earthquake damage. This means that many houses should survive the disaster.