5 US Companies With The Highest Profit Margins

4. Pfizer Inc. (NYSE:PFE)

2022 Profit Margin: 31.4%

Pfizer Inc. (NYSE:PFE) is a renowned pharmaceutical company with a wide range of high-quality medicines. Despite the impact of the COVID-19 pandemic, Pfizer has developed a widely accepted COVID-19 vaccine. In 2022, the company achieved a net income of around $31.4 billion, with a revenue of $100 billion. Pfizer Inc. (NYSE:PFE)’s commitment to innovation is evident through its $11.4 billion investment in research and development in 2022, an increase of over 10% from 2021.