5 New Alternatives to Antibiotics: Alternative Therapeutic Strategies to Treat Antibiotic-Resistant Pathogens

2. Efflux Pump Inhibitors 

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Efflux pump inhibitors (EPIs) are emerging as new alternative antibiotics by targeting efflux mechanisms, critical components of antibiotic resistance. Classified into plant-based, synthetic, and microbial-derived, they either decouple energy from efflux pumps or directly inhibit them. Promising in laboratory settings, EPIs reduce bacterial resistance and have clinical efficacy, notably MP-601,205 for respiratory infections. Clinical trials show efficacy in treating malignancies. Ongoing efforts focus on developing novel EPIs through various approaches, holding promise against antibiotic resistance. Research uncovers inhibitors through diverse methods, while ongoing efforts aim to optimize EPIs for better therapeutic potential.