5 Most Depressed States in the US

3. West Virginia 

Depression Rate per 100,000 People: 26,874 

West Virginia is one of the saddest states in the US with a depression rate of 26,874 per 100,000 people. The state has one of the highest numbers of mental illnesses in the US. The most recent data from the West Virginia MATCH Survey (2021-2022) revealed that Boone County had the highest rate of depression, anxiety, or PTSD at 32%, followed by Logan County at 27.4%.