5 Countries with Most Antidepressant Users in the World

3. Spain 

Annual Sales Per Capita (2021): $15.10 

Spain, standing third among the top countries with most antidepressant users, has seen a significant rise in antidepressant consumption, with SSRIs being the most used type, accounting for 4.99% of consumption. Escitalopram has surpassed citalopram as the most widely used antidepressant. Antidepressant non-adherence rates in Spain exceed 20% for medications like fluoxetine, fluvoxamine, and vortioxetine. In 2021, 10.6% of the population used antidepressants, with 19.9% non-adherent. Fluoxetine, the least expensive, has the highest costs associated with non-adherence. Economic evaluation in Castile and Leon in 2021 focused on patients using at least one antidepressant that year.