5 Cities with the Highest Opioid Deaths in the U.S.

In this piece, we will take a look at five cities with the highest opioid deaths in the U.S. For more cities, head on over to 20 Cities with the Highest Opioid Deaths in the U.S.

5. Louisville, Kentucky

Opioid-related drug overdose deaths (per 100,000 population, age-adjusted): 51.2

Louisville is the largest city in Kentucky, with a population of nearly seven hundred thousand people. The city is one of the most important centers for the shipping and cargo industries in America. This has also been made possible due to its central location in Kentucky, and Louisville also houses important manufacturing facilities since it is easier to ship raw materials and finished goods to and from the manufacturing plants.

4. Philadelphia, Pennsylvania

Opioid-related drug overdose deaths (per 100,000 population, age-adjusted): 53,5

Philadelphia ranks in the list of the top ten cities in America in terms of population. However, while it is the sixth most populous city with a population of 1.6 million, its opioid related overdose deaths make it rank fourth on our list. Philadelphia is also one of the most historic cities in America. It is known to be the founding place of the U.S., being a regular meeting point of the Founding Fathers before the American Revolution. Naturally, this also made it the first capital of the United States of America.

3. Columbus, Ohio

Opioid-related drug overdose deaths (per 100,000 population, age-adjusted): 54.1

Columbus, as you might have guessed, is named after Christopher Columbus. However, this was primarily due to adoration for the explorer that would set the stage for the world’s most powerful country, as Columbus is an inland city without a port. It houses close to a million people and is the capital of Ohio. Columbus also has a well developed economy, made of several different sectors and industries such as aviation, healthcare, and logistics.

2. Cleveland, Ohio

Opioid-related drug overdose deaths (per 100,000 population, age-adjusted): 58.5

Cleveland makes Ohio the only state to appear twice on our list of cities with the most opioid related deaths. Cleveland was founded a handful of years before the turn of the nineteenth century. It houses several important Fortune 500 firms and is known for Cleveland Clinic which is one of the best hospitals in the U.S.

1. Baltimore, Maryland

Opioid-related drug overdose deaths (per 100,000 population, age-adjusted): 109.5

Baltimore has a population of more than half a million people and it is the largest city in Maryland. It was founded in 1730, well before the American Revolution. It is a hub for world trade in its state and renowned for its Johns Hopkins Hospital.

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