5 Cities with the Highest Depression Rates in the U.S.

3. Knoxville, Tennessee

Percentage of Residents With Depression: 30.20%

Knoxville is one of the largest cities in Tennessee, with a population of close to two hundred thousand people. Like Charleston, Knoxville is also one of the oldest cities in America, since it was first settled in 1786. This also led to tensions between the settlers and the Native American Cherokee tribe. The city houses one of America’s largest utilities, and it also houses several fast food, entertainment, and financial firms.