5 Biggest US Cities Facing Depopulation by 2100

2. Birmingham, AL

Five-Year Change: -7.7%

Annual Loss Rate: 0.74%

Birmingham’s population reached its peak in 1960 at roughly 340,000. However, since that peak, the city has faced a continuous decline in population. Several key factors contributed to this demographic shift, including the loss of manufacturing jobs due to the decline in heavy industries, the city’s reliance on traditional economic sectors, and the growth of suburban areas, which led to the migration of residents away from the city centers.