28. Caseyville Ave/N Park Dr, East Street, St Louis, IL
Crime rate: 66.27 per 1,000 people
In forums like Reddit and Topix, people usually say East St Louis is the most dangerous neighborhoods in America. In fact, according to The Active Times, ” In 2014 the murder rate alone was higher than that of Honduras, which has the highest in the world, at 90.4 per 100,000 people.”