1. Bay City, Michigan
Annual median income: $38,008
Finally, on the top of our list of the poorest large major cities in America in 2018 is the Bay City in Michigan! The most popular occupations in this city are the Administrative Assistant, Retail Store Manager, and Information Technology Director. However, you wouldn’t be that happy if you are the Certified Nurse Assistant as you would get just $11 per hour. On the other hand, for a registered nurse the salary is $30 per hour!