3. El Paso, Texas
Annual median income: $40,668
The cost of living is 10.5 percent below the national average in El Paso, the number three on our list of poorest large major cities in America in 2018. Some of the lowest paid job positions are the Office Manager with $39,738 and the General Manager of a restaurant with $41,118. The highest one goes around $58,000 which is, as you can see by yourselves, not much higher than the average.