4. Fresno, California
Annual median income: $44,598
Fresno has 5.5 percent higher cost of living than the national average. The wages can be very high with reaching $88,918, but at the same time, they can go as low as $40,785. The most popular occupations are the Office Manager, Operations Manager, and Human Resources Manager whose pay can be between $40,785 and $65,885 annually.
![Poorest Large Major Cities in America in 2018](https://imonkey-blog.imgix.net/blog/wp-content/uploads/2016/02/10044804/shutterstock_291778172-750x500.jpg?auto=fortmat&fit=clip&expires=1770422400&width=480&height=320)
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