2. St. Louis, Missouri
Total STDs: 5,942
Total STDs per 100,000: 1867.54
Missouri couldn’t escape from being on our list of most sexually diseased cities in America since there are 5,942 people who have sexually transmitted disease in St. Louis compared to its 318,000 population. 4,128 cases of chlamydia were reported alongside 1,754 cases of gonorrhea and 39 cases of syphilis.

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