8. New Orleans, Louisiana
Total STDs: 5,614
Total STDs per 100,000: 1520.37
New Orleans has close to 350,000 residents and is the largest city of Louisiana State. As it turns out, it is also the one with most sexual diseases. Out of the 5,614 STDs reported, 4,064 were referring to chlamydia infections, 1,485 to gonorrhea while 65 cases were syphilis related.