9. Insidious (2010)
Profit: $34,949,474
Budget: $1,500,000
Following the success of the first movie in this horror series, the makers of Insidious have since released a sequel and a prequel but none were as profitable as the original. That is not to say they were unsuccessful of course. Both of them managed to scoop up quite a lot of box office gold, but could not make it to our list of most profitable movies based on return on investment.