4. Luxembourg City, Luxembourg
Average Cost Per Week: $1,221
Over twelve hundred dollars a week for a single person is quite a lot of money, but the nature of the list is as such, and you can imagine things are only going to get more expensive as we move up in the list. Luxembourg City, next on our list of most expensive cities to spend a week in Europe, is an awesome place to visit, as it offers every possible amenity that a modern tourist desires, and when it comes to sightseeing, Luxembourg does not disappoint one bit. Grand Ducal Palace, Notre-Dame Cathedral, Mudam Art Museum and Gëlle Fra are just a few of them.