15 Best Selling Most Profitable Drugs of All Time

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5. Plavix

Plavix is used to reduce the chances of heart disease and stroke. The drug is normally used with aspirin and is prescribed after the placement of coronary artery stents. Plavix was produced by France-based Sanofi SA (ADR) (NYSE:SNY) and Bristol-Myers Squibb. In the second-quarter of 2017, Sanofi reported a 0.3% decline in Plavix sales. The drug is under pressure amid tough competition from similar products like Brilianta, which is marketed by AstraZeneca, and Xarelto, which is manufactured by Johnson & Johnson. Plavix’s total revenue is over $82.32 billion.

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