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15 Best Biotech Stocks to Buy According to Billionaires

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In this article, we will be taking a look at the 15 best biotech stocks to buy according to billionaires.

Although biotech stocks had a “challenging” year in 2024, JPMorgan believes that some of the industry’s companies could see significant growth in the months to come. Senior partner and principal of investments at Novo Holdings, Johan Hueffer, spoke on CNBC on November 28 about his macro outlook for life sciences investments. He claimed that in the past few years, biotechs have had trouble raising funding. Over the past quarter or two, though, that tendency has begun to improve.

Nonetheless, there have been effects on businesses that specifically support the pharmaceutical sector, including contract manufacturing organizations (CMOs), research and development tools providers, and contract research organizations (CROs). Similar patterns have been noted for businesses that produce production tools for the biotech and pharmaceutical sectors. Although there have been ups and downs in these sectors over the last two years, the patterns are now beginning to stabilize. According to Hueffer, there is a lot of potential in the sector right now.

Goldman Sachs Highlights Undervalued Biotech Sector Amid Fed Rate Cuts 

Likewise, Goldman Sachs clarified biotech as a frequently disregarded area of the investment world. John Flood, Head of Americas Equities Sales Trading at Goldman, wrote in a letter to clients that biotech equities offered an unnoticed opportunity for investors hoping to profit from the Fed’s recent rate decreases. Because biotech equities are sensitive to interest rate changes and frequently depend on anticipated future revenues, they are particularly impacted. The cost of capital has a significant effect on these equities as well. These equities have substantial upside potential and, should clinical studies be successful, offer an “option-like structure,” even though they are now quite unprofitable. Because of this, they are particularly sensitive to shifts in interest rates.

The Fed has lowered the funds rate by one full point since September. The present market pricing indicates that there will only be one or two additional declines in 2025, according to CNBC. The Federal Open Market Committee (FOMC) members voted to lower the central bank’s benchmark borrowing rate to the 4.25%–4.5% target range, according to a January 8 CNBC report. But they also trimmed their projections for anticipated rate cuts in 2025, assuming quarter-point increases, from four to two.

Flood’s report also emphasized how the biotech sector has recently demonstrated better fundamentals, which have been ascribed to superior clinical outcomes and a more favorable regulatory environment. Goldman’s data shows that hedge funds continue to underinvest in biotechnology despite these tailwinds. Over the previous year, the industry’s hedge fund’s long/short positioning placed it in the 13th percentile. In addition, for the previous five years, it was in the fourth percentile.

With these trends in view, let’s look at the 15 Best Biotech Stocks to Buy According to Billionaires.

A scientist in a lab conducting research on cell-based therapeutics and biotechnology.

Our Methodology 

For our methodology, we selected biotech stocks from the Insider Monkey billionaire database, as of Q4 2024, focusing on those with the highest number of billionaire holdings. We then ranked these stocks based on the number of billionaire investors. In cases where multiple stocks had the same number of billionaire holders, we used the dollar value of billionaire holdings as a tiebreaker, placing stocks with lower dollar values first in ascending order.

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Here is our list of the 15 best biotech stocks to buy according to billionaires.

15. Cogent Biosciences, Inc. (NASDAQ:COGT)

Number of Billionaires: 12 

Dollar Value of Billionaire Holdings: $94,931,294 

Cogent Biosciences, Inc. (NASDAQ:COGT) is a biotechnology company focused on developing precision therapies for genetically defined diseases. Fundamentally, the business creates and develops small molecule therapies to address uncommon illnesses with substantial unmet medical needs. The main goal of the company is to develop therapies for illnesses caused by genetic abnormalities, especially in the field of oncology.

Cogent Biosciences, Inc. (NASDAQ:COGT)’s latest financial report which was released on February 25, 2025, highlights significant progress in its clinical trials. The SUMMIT trial for NonAdvSM expects results by July 2025, while the APEX trial for AdvSM has completed enrollment, with top-line data anticipated in the second half of 2025. Additionally, the PEAK trial for 2nd-line GIST is set to report results by the end of the year.

Financially, the company maintains a strong cash position, with $312 million available to sustain operations into late 2026. Its R&D expenses rose to $62 million in Q4 2024 and $232.7 million for the full year, reflecting the accelerated development of Bezuclastinib and other research programs. Its strong financial position and promising pipeline have positioned it among the best biotech stocks. General and administrative costs also increased due to organizational growth. As a result, net losses widened to $67.9 million in Q4 and $255.9 million for the full year, which was driven by higher spending to advance drug candidates.

In February 2025, Cogent Biosciences, Inc. (NASDAQ:COGT) presented promising updates from the SUMMIT and APEX trials at the American Society of Hematology (ASH) meeting, showing notable improvements in non-advSM and encouraging results in AdvSM patients. Additionally, the company expanded its pipeline by adding a potent and selective KRAS inhibitor, signaling its commitment to developing groundbreaking treatments.

14. Neurocrine Biosciences, Inc. (NASDAQ:NBIX)

Number of Billionaires: 12 

Dollar Value of Billionaire Holdings: $1,126,924,284 

Neurocrine Biosciences, Inc. (NASDAQ:NBIX) is a biopharmaceutical company focused on developing treatments for neurological, neuroendocrine, and neuropsychiatric disorders, including tardive dyskinesia, Parkinson’s disease, and endometriosis. The company stands out for its specialized focus on neuroscience-based treatments and a strong research and development pipeline aimed at addressing complex neurological and endocrine-related disorders.

Neurocrine Biosciences, Inc. (NASDAQ:NBIX)’s flagship product, INGREZZA, is used to treat tardive dyskinesia and chorea in Huntington’s disease. The company also offers CRENESSITY, a first-in-class treatment for congenital adrenal hyperplasia (CAH), and has ongoing collaborations for treatments for endometriosis and uterine fibroids. The corporation’s pipeline includes potential therapies for major depressive disorder, schizophrenia, and epilepsy, making it one of the best biotech stocks to watch.

In its Q4 2024 financial report, Neurocrine Biosciences, Inc. (NASDAQ:NBIX) saw strong growth, with INGREZZA sales reaching $615 million in Q4, a 23% increase from the previous year. Full-year INGREZZA sales were $2.3 billion, a 26% increase. The newly launched CRENESSITY contributed $2 million in sales, and total Q4 revenue was $627.7 million, up 22% from Q4 2023. The company’s R&D expenses grew to $185.6 million due to investments in new treatments, and they initiated Phase 3 programs for osavampator (for major depressive disorder) and NBI-‘568 (for schizophrenia).

Neurocrine Biosciences, Inc. (NASDAQ:NBIX) ended 2024 with a strong cash position of $1.8 billion and expects INGREZZA sales to reach between $2.5 billion and $2.6 billion in 2025. Additionally, the company launched a $300 million share repurchase program and saw positive developments like the Medicare exemption for INGREZZA and a strategic collaboration amendment with Takeda, which grants the business exclusive rights for osavampator in most territories. These factors position the corporation for continued growth and success.

13. Intra-Cellular Therapies, Inc. (NASDAQ:ITCI)  

Number of Billionaires: 13 

Dollar Value of Billionaire Holdings: $374,638,998 

Intra-Cellular Therapies, Inc. (NASDAQ:ITCI) is a biopharmaceutical company focused on developing small-molecule drugs for neuropsychiatric and neurological disorders, such as schizophrenia, bipolar disorder, and major depressive disorder. Its flagship product, CAPLYTA (lumateperone), is an FDA-approved treatment for schizophrenia and bipolar depression, addressing critical unmet medical needs in these areas.

Intra-Cellular Therapies, Inc. (NASDAQ:ITCI) reported strong financial results for Q4 and full-year 2024. CAPLYTA is the company’s primary drug which saw a 51% increase in Q4 net product sales, reaching $199.2 million, and a 47% growth for the full year, totaling $680.5 million. This reflects CAPLYTA’s growing market acceptance.

The company also received FDA acceptance for a supplemental New Drug Application (sNDA) for lumateperone as an adjunctive treatment for major depressive disorder (MDD), which could significantly expand its market. However, Intra-Cellular Therapies, Inc. (NASDAQ:ITCI) experienced increased spending, with SG&A expenses rising to $504.5 million due to commercialization and infrastructure costs, and R&D expenses growing to $236.1 million for ongoing projects.

Despite these costs, Intra-Cellular Therapies, Inc. (NASDAQ:ITCI) ended the year with a strong cash position of $1.0 billion, up from $499.7 million in 2023, providing financial flexibility for future trials and commercialization efforts.

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