13G Filing: Point72 Asset Management and Karyopharm Therapeutics Inc. (KPTI)

Item 2(d)

Title of Class of Securities:

Common Stock, par value $0.0001 per share

Item 2(e)

CUSIP Number:

48576U106

Item 3

Not Applicable

Item 4

Ownership:

The percentages used herein are calculated based upon the Shares issued and outstanding as of October 30, 2017, as reported on the Issuer’s quarterly report on Form 10-Q filed with the Securities and Exchange Commission by the Issuer for the quarterly period ended September 30, 2017.

As of the close of business on November 3, 2017:

1.  Point72 Asset Management, L.P.

(a) Amount beneficially owned: 3,466,000

(b) Percent of class: 7.3%

(c)(i) Sole power to vote or direct the vote: -0-

(ii) Shared power to vote or direct the vote: 3,466,000

(iii) Sole power to dispose or direct the disposition: -0-

(iv) Shared power to dispose or direct the disposition: 3,466,000

2.  Point72 Capital Advisors, Inc.

(a) Amount beneficially owned: 3,466,000

(b) Percent of class: 7.3%

(c)(i) Sole power to vote or direct the vote: -0-

(ii) Shared power to vote or direct the vote: 3,466,000

(iii) Sole power to dispose or direct the disposition: -0-

(iv) Shared power to dispose or direct the disposition: 3,466,000

3.  Cubist Systematic Strategies, LLC

(a) Amount beneficially owned: 963

(b) Percent of class: less than 0.1%

(c)(i) Sole power to vote or direct the vote: -0-

(ii) Shared power to vote or direct the vote: 963

(iii) Sole power to dispose or direct the disposition: -0-

(iv) Shared power to dispose or direct the disposition: 963

4.  Point72 Asia (Hong Kong) Limited

(a) Amount beneficially owned: 334

(b) Percent of class: less than 0.1%

(c)(i) Sole power to vote or direct the vote: -0-

(ii) Shared power to vote or direct the vote: 334

(iii) Sole power to dispose or direct the disposition: -0-

(iv) Shared power to dispose or direct the disposition: 334