13G Filing: Perceptive Advisors and Motus GI Holdings Inc (MOTS)

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Item 1(a).

Name of Issuer:

Motus GI Holdings, Inc. (the Issuer)

Item 1(b).

Address of Issuers Principal Executive Offices:

1301 East Broward
Boulevard, 3^rd Floor

Ft. Lauderdale, FL 33301

Item 2(a).

Names of Persons Filing:

The names of the persons filing this report
(collectively, the Reporting Persons) are:

Perceptive Advisors LLC (Perceptive Advisors)

Joseph Edelman (Mr. Edelman)

Perceptive Life Sciences Master Fund, Ltd. (the Master Fund)

Item 2(b).

Address of Principal Business Office or, if None, Residence:

The address of the
principal business office of each of the Reporting Persons is:

51 Astor Place, 10th Floor

New York, NY 10003

Item 2(c).

Citizenship:

Perceptive Advisors is a Delaware limited liability company

Mr. Edelman is a United States citizen

The Master Fund is a Cayman Islands corporation

Item 2(d).

Title of Class of Securities:

Common Stock, $0.0001 par
value per share (Common Stock)

Item 2(e).

CUSIP Number:

62014P108

Item 3.

If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

Not applicable.

Item 4.

Ownership.

The information required by this item with respect to each Reporting
Person is set forth in Rows 5 through 9 and 11 of the cover page to this Schedule 13G. The ownership percentages reported are based on 15,572,972 outstanding shares of Common Stock, as reported in the Issuers prospectus filed on
February 15, 2018.