13G Filing: Partner Fund Management and Medicines Co (MDCO)

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Ownership Summary Table

Name Sole Voting Power Shared Voting Power Sole Dispositive Power Shared Dispositive Power Aggregate Amount Owned Power Percent of Class
Partner Fund Management 0 3,881,971 0 5.3%
Partner Fund Management GP 0 3,881,971 0 5.3%
Partner Investment Management 0 72,502 0 0.1%
Partner Investment Management GP 0 72,502 0 0.1%
Brian D. Grossman 0 3,954,473 0 5.4%
Christopher M. James 0 3,954,473 0 5.4%

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Page 1 of 13 – SEC Filing

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

SCHEDULE 13G

(Rule 13d-102)

 

Information Statement Pursuant to Rules 13d-1
and 13d-2

Under the Securities Exchange Act of 1934

(Amendment No. )*

The Medicines Company
(Name of Issuer)
Common stock, par value $0.001 per share
(Title of Class of Securities)
584688105
(CUSIP Number)
April 21, 2017
Date of Event Which Requires Filing of the Statement

Check the appropriate box to designate the
rule pursuant to which this Schedule is filed:

¨ Rule 13d-1(b)
x Rule 13d-1(c)
¨ Rule 13d-1(d)

*The remainder of this cover page shall be
filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for
any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of
this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934
(“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).

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Page 2 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 2 of 13 Pages
1. NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Partner Fund Management, L.P.
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)         ¨
(b)        x

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

3,881,971 shares 

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above

10.

CHECK BOX IF
THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES

CERTAIN SHARES

¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.3%1

 

12.

TYPE OF REPORTING PERSON

IA; PN

1 The percentages reported in this Schedule 13G are based upon approximately 72,939,570 shares outstanding (comprised of (i) 72,136,728
shares of common stock outstanding as of April 21, 2017 according to the Definitive Proxy on Schedule 14A filed by the issuer with
the Securities and Exchange Commission on April 26, 2017, and (ii) approximately 802,842 shares of common stock issuable upon
the exercise of certain convertible bonds owned by the reporting persons’ affiliates). All of the other numbers and percentages
reported in this Schedule 13G are as of 9:00 a.m. (ET) on the date of filing.

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Page 3 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 3 of 13 Pages
1. NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Partner
Fund Management GP, LLC
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)         ¨
(b)        x

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

3,881,971 shares

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above

10.

CHECK BOX IF
THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES

CERTAIN SHARES

¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.3%

12.

TYPE OF REPORTING PERSON

OO

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Page 4 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 4 of 13 Pages
1. NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Partner Investment Management, L.P.
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)         ¨
(b)        x

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

72,502 shares 

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above

10.

CHECK BOX IF
THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES

CERTAIN SHARES

¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

0.1%

12.

TYPE OF REPORTING PERSON

IA; PN

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Page 5 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 5 of 13 Pages
1. NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Partner
Investment Management GP, LLC
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)         ¨
(b)        x

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

72,502 shares 

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above

10.

CHECK BOX IF
THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES

CERTAIN SHARES

¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

0.1%

12.

TYPE OF REPORTING PERSON

OO

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Page 6 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 6 of 13 Pages
1. NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Brian
D. Grossman
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)         ¨
(b)        x

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

U.S. Citizen

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

3,954,473 shares 

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above

10.

CHECK BOX IF
THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES

CERTAIN SHARES

¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.4%

12.

TYPE OF REPORTING PERSON

IN

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Page 7 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 7 of 13 Pages
1. NAME OF REPORTING PERSON
S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Christopher
M. James
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a)         ¨
(b)        x

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

U.S. Citizen

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

3,954,473 shares 

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above

10.

CHECK BOX IF
THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES

CERTAIN SHARES

¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

5.4%

12.

TYPE OF REPORTING PERSON

IN

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Page 8 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 8 of 13 Pages
Item 1(a) Name of Issuer

The Medicines Company

 

Item 1(b) Address of Issuer’s Principal Executive Offices
8 Sylvan Way, Parsippany, New Jersey 07054

 

Item 2(a) Name of Person Filing

This Schedule 13G is being jointly filed
by Partner Fund Management, L.P. (“PFM”), Partner Fund Management GP, LLC (“PFM-GP”), Partner Investment
Management, L.P. (“PIM”), Partner Investment Management GP, LLC (“PIM-GP”), Brian D. Grossman (“Grossman”)
and Christopher M. James (“James” and, collectively with PFM, PFM-GP, PIM, PIM-GP and Grossman, the “Reporting
Persons”) with respect to shares of common stock (and options to purchase and/or other securities convertible into common
stock) of the above-named issuer owned by PFM Healthcare Master Fund, L.P., a Cayman Islands limited partnership (“HCM”),
PFM Healthcare Opportunities Master Fund, L.P., a Cayman Islands limited partnership (“HCOPP”), PFM Healthcare Principals
Fund, L.P., a Delaware limited partnership (“HCP”), PFM Healthcare Emerging Growth Master Fund, L.P., a Cayman Islands
limited partnership (“HEGM”), PFM Global Long Alpha Master Fund, L.P., a Cayman Islands limited partnership (“GLAM”),
PFM Diversified Principals Fund, L.P., a Delaware limited partnership (“DP”), PFM Diversified Master Fund, L.P., a
Cayman Islands limited partnership (“DM”), PFM Diversified Institutional Master Fund, L.P., a Cayman Islands limited
partnership (“DI” and, collectively with HCM, HCOPP, HCP, HEGM, GLAM, DP and DM, the “Funds”).

PFM is the investment advisor
for HCM, HCOPP, HEGM, GLAM, DM and DI. PIM is the investment advisor for HCP and DP. PFM-GP and PIM-GP are, respectively, the
general partners of PFM and PIM. Grossman is the portfolio manager for the health care strategy for the Funds. James is the portfolio
manager for the diversified strategy for the Funds. Grossman and James are co-managing members of PFM-GP and PIM-GP.

The filing of this statement shall not be construed as an admission that any of the Reporting Persons is the beneficial owner
of any securities covered by the statement other than the securities actually owned by such person (if any).

 

Item 2(b) Address of Principal Business Office

The address of the principal business
office of each of the Reporting Persons is c/o Partner Fund Management, L.P., 4 Embarcadero Center, Suite 3500, San Francisco,
CA 94111.

Item 2(c) Citizenship

Each
of PFM and PIM is organized as a limited partnership under the laws of the State of Delaware. Each of PFM-GP and PIM-GP is organized
as a limited liability company under the laws of the State of Delaware. Each of Grossman and James is a U.S. citizen.

Item 2(d) Title of Class of Securities

Common stock, $0.001
par value

 

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Page 9 of 13 – SEC Filing

 

CUSIP No. 584688105 13G Page 9 of 13 Pages

 

Item 2(e) CUSIP Number

584688105

Item 3 If this statement is filed pursuant to Rules 13d-1(b),
or 13d-2(b) or (c), check whether the person filing is a:
(a) ¨ Broker or dealer registered under Section 15 of the Exchange Act;
(b) ¨ Bank as defined in Section 3(a)(6) of the Exchange Act;
(c) ¨ Insurance company as defined in Section 3(a)(19) of the Exchange Act;
(d) ¨ Investment company registered under Section 8 of the Investment Company Act;
(e) ¨ An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);
(f) ¨ An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F);
(g) ¨ A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G);
(h) ¨ A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;
(i) ¨ A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act;
(j) ¨ Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If filing as a
non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J), please specify the type of institution: ____________.

 

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Page 10 of 13 – SEC Filing

 

CUSIP No. 584688105 13G Page 10 of 13 Pages
Item 4 Ownership
A. Partner Fund Management, L.P. and Partner Fund Management
GP, LLC
(a) PFM and PFM-GP may be deemed to beneficially own 3,881,971 shares of Common Stock.
(b) The number of shares PFM and PFM-GP may be deemed to beneficially own constitutes approximately 5.3%
of the Common Stock outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 0
(ii) shared power to vote or to direct the vote: 3,881,971
(iii) sole power to dispose or to direct the disposition of: 0
(iv) shared power to dispose or to direct the disposition of: 3,881,971
B. Partner Investment Management, L.P. and Partner Investment Management GP, LLC
(a) PIM and PIM-GP may be deemed to beneficially own 72,502 shares of Common Stock.
(b) The number of shares PIM and PIM-GP may be deemed to beneficially own constitutes approximately 0.1%
of the Common Stock outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 0
(ii) shared power to vote or to direct the vote: 72,502
(iii) sole power to dispose or to direct the disposition of: 0
(iv) shared power to dispose or to direct the disposition of: 72,502

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Page 11 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 11 of 13 Pages
C. Brian D. Grossman
(a) Grossman may be deemed to beneficially own 3,954,473 shares of Common Stock.
(b) The number of shares Grossman may be deemed to beneficially own constitutes approximately 5.4% of
the Common Stock outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 0
(ii) shared power to vote or to direct the vote: 3,954,473
(iii) sole power to dispose or to direct the disposition of: 0
(iv) shared power to dispose or to direct the disposition of: 3,954,473
D. Christopher M. James
(a) James may be deemed to beneficially own 3,954,473 shares of Common Stock.
(b) The number of shares James may be deemed to beneficially own constitutes approximately 5.4% of the
Common Stock outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 0
(ii) shared power to vote or to direct the vote: 3,954,473
(iii) sole power to dispose or to direct the disposition of: 0
(iv) shared power to dispose or to direct the disposition of: 3,954,473

 

Item 5 Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial
owner of more than 5 percent of the class of securities, check the following ¨.

 

Item 6 Ownership of More than Five Percent on Behalf of Another
Person
Not Applicable

 

Item 7 Identification and Classification of the Subsidiary
which Acquired the Security Being Reported on by the Parent Holding Company
See Item 2 above

 

Item 8 Identification and Classification of Members of the
Group
Not Applicable

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Page 12 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 12 of 13 Pages
Item 9 Notice of Dissolution of Group
Not Applicable
Item 10 Certification

By signing
below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held
for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired
and are not held in connection with or as a participant in any transaction having that purpose or effect.

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Page 13 of 13 – SEC Filing

CUSIP No. 584688105 13G Page 13 of 13 Pages

After reasonable inquiry
and to the best of its knowledge and belief, the undersigned certify that the information set forth in this statement is true,
complete and correct.

Dated this 1st day of May, 2017.

PARTNER FUND MANAGEMENT, L.P. PARTNER FUND MANAGEMENT GP, LLC
By: Partner Fund Management GP, LLC By: /s/ Darin Sadow
its general partner Darin Sadow, Authorized Signatory
By: /s/ Darin Sadow
Darin Sadow, Authorized Signatory
PARTNER INVESTMENT MANAGEMENT, L.P. PARTNER INVESTMENT MANAGEMENT GP, LLC
By: Partner Investment Management GP, LLC,
its general partner By: /s/ Darin Sadow
Darin Sadow, Authorized Signatory
By: /s/ Darin Sadow
Darin Sadow, Authorized Signatory
BRIAN D. GROSSMAN CHRISTOPHER M. JAMES
By: /s/ Darin Sadow By: /s/ Darin Sadow
Darin Sadow, attorney-in-fact* Darin Sadow, attorney-in-fact**
* Darin Sadow is signing on behalf of Brian Grossman as attorney-in-fact pursuant to a power of attorney
dated August 4, 2011, and incorporated by reference herein. The power of attorney was filed as an attachment to a filing by certain
of the Reporting Persons on Schedule 13G for K-V Pharmaceutical Company on August 5, 2011.

 

** Darin Sadow is signing on behalf of Christopher M. James
as attorney-in-fact pursuant to a power of attorney dated August 4, 2011, and incorporated by reference herein. The power of attorney
was filed as an attachment to a filing by certain of the Reporting Persons on Schedule 13G for K-V Pharmaceutical Company on August
5, 2011.

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