Page 7 of 8 – SEC Filing
Item 3. If this statement is
filed pursuant to rule 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a) [ ] Broker or dealer registered
under section 15 of the Act (15 U.S.C. 78o).
(b) [ ] Bank as defined in section
3(a)(6) of the Act (15 U.S.C. 78c).
(c) [ ] Insurance company as
defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
(d) [ ] Investment company registered
under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
(e) [ x ] An investment
adviser in accordance with section 240.13d-1(b)(1)(ii)(E) (as to PAI).
(f) [ ] An employee benefit plan
or endowment fund in accordance with section 240.13d-1(b)(1)(ii)(F).
(g) [ x ] A parent holding
company or control person in accordance with 240.13d-1(b)(1)(ii)(G) (as to Dr. Lee and Dr. Yun).
(h) [ ] A savings association
as defined in section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813).
(i) [ ] A church plan that is
excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3).
(j) [ ] A non-U.S. institution
in accordance with §240.13d-1(b)(ii)(J).
(k) [ ] Group, in accordance
with Rule 13d-1(b)(1)(ii)(K).
If filing as a non-U.S. institution
in accordance with §240.13d-1(b)(1)(ii)(J), please specify the type of institution _______________________________________________________________.
Item 4. Ownership.
See Items 5-9 and 11 of the cover page for each Filer.
Item 5. Ownership of Five Percent
or Less of a Class
If this statement is being filed to report the fact that as of the
date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check
the following [ ].
Item 6. Ownership of More than
Five Percent on Behalf of Another Person.
PAI is a registered investment adviser and is the general partner
and investment adviser of investment limited partnerships, and is the investment adviser to Healthcare Master II and other investment funds. PAI’s
clients have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Stock.
No individual client other than Healthcare Master II separately holds more than five percent of the outstanding Stock.
Item 7. Identification and Classification
of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.
Not applicable.
Item 8. Identification and Classification
of Members of the Group.
Dr. Lee and Dr. Yun co-manage PAI. The Filers are filing this Schedule
13G jointly, but not as members of a group, and each of them expressly disclaims membership in a group. Each Filer disclaims beneficial
ownership of the Stock except to the extent of that Filer’s pecuniary interest therein.
Item 9. Notice of Dissolution
of Group.
Not applicable.
Item 10. Certification of PAI LLC, Dr. Lee, Dr. Yun, Healthcare Master II.
By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and
are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were
not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.
Exhibits
Exhibit A Joint Filing Agreement.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and correct.
Dated: April 3, 2017
| PALO ALTO INVESTORS, LLC By: /s/Angela Nguyen-Dinh, Chief Compliance Officer | |
| PALO ALTO HEALTHCARE MASTER FUND II, L.P.
By: Palo Alto Investors, By: /s/ Angela Nguyen-Dinh, Chief Compliance Officer | |
| /s/ Patrick Lee, MD | /s/ Anthony Joonkyoo Yun, MD |
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