13G Filing: Knoll Capital Management Raises Stake in Synthetic Biologics, Inc. (SYN)

Cusip No.  87164U102

13G

Page 6 of 7 Pages

If filing as a non-U.S.
institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution: _________________

Item 4.

Ownership:

Provide the following information regarding
the aggregate number and percentage of class of securities of the issuer identified in Item 1.

(a)

Amount beneficially owned:

As of this filing:

Gakasa beneficially
owns 4,754,557 Shares of the Issuer’s Common stock, which is comprised of 3,734,149 Shares of the Issuer’s Common Stock
and warrants to purchase 1,020,408 shares of Common Stock.

Each of KCMLP and Knoll
beneficially own 4,754,557 Shares of the Issuer’s Common Stock, which is comprised of 3,734,149 Shares of the Issuer’s
Common Stock and warrants to purchase 1,020408 shares of Common Stock. KCMLP has trading authority for Gakasa, and Knoll is the
President of KCMLP.

(b)

Percent of Class:

The 4,754,557 shares
of the Issuer’s Common Stock beneficially owned by each of Gakasa, KCMLP and Knoll constitute 5.2% of the Issuer’s
Common Stock outstanding.

This percentage is
calculated based on a total of 90,810,086 shares of Common Stock outstanding, as reported by the Issuer on a Form 10-Q filed with
the SEC on November 5, 2015.

(c)

Number of shares as to which such person has:

(i)

sole power to vote or to direct the vote: 0

(ii)

shared power to vote or to direct the vote: 4,754,557

KCMLP, Knoll
and Gakasa share the power to vote or direct the vote of those shares of Common Stock owned by Gakasa.

(iii)

sole power to dispose or to direct the disposition of: 0

(iv)

shared power to dispose or to direct the disposition of: 4,754,557

KCMLP, Knoll
and Gakasa share the power to dispose of or direct the disposition of those shares of Common Stock owned by Gakasa.

Item 5.

Ownership of Five Percent or Less of a Class:

If this statement is
being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than
5 percent of the class of securities, check the following ¨.

Item 6.

Ownership of More than Five Percent on Behalf of Another Person:

Not Applicable.

Item 7.

Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company or Control Person:

Not Applicable.

Item 8.

Identification and Classification of Members of the Group:

Not Applicable.

Item 9.

Notice of Dissolution of Group:

 

Not Applicable

Item 10.

Certifications:

By Signing below I certify that, to the
best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with
the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.