13G Filing: James E. Flynn and Proteon Therapeutics Inc (PRTO)

74371L109

A parent holding company or control person in accordance
with Rule 13d-1(b)(1)(ii)(G);

(h)

A savings association as defined in Section 3(b) of
the Federal Deposit Insurance Act;

A church plan that is excluded from the definition
of an investment company under Section 3(c)(14) of the Investment Company Act;

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

Deerfield Mgmt, L.P. – 347,100 shares

Deerfield Mgmt III, L.P. – 877,799 shares

Deerfield Management Company, L.P. – 1,224,899 shares

Deerfield Special Situations Fund, L.P. – 149,676
shares

Deerfield Partners, L.P. – 86,867 shares

Deerfield International Master Fund, L.P. –
110,557 shares

Deerfield Private Design Fund III, L.P. –
877,799 shares

James E. Flynn – 1,224,899 shares

Deerfield Mgmt, L.P. – 2.07%

Deerfield Mgmt III, L.P. – 5.23%

Deerfield Management Company, L.P. – 7.30%

Deerfield Special Situations Fund, L.P. –
0.89%

Deerfield Partners, L.P. – 0.52%

Deerfield International Master Fund, L.P. –
0.66%

Deerfield Private Design Fund III, L.P. –
5.23%

James E. Flynn – 7.30%

Deerfield Mgmt, L.P. – 347,100

Deerfield Mgmt III, L.P. – 877,799

Deerfield Management Company, L.P. – 1,224,899

Deerfield Special Situations Fund, L.P. – 149,676

Deerfield Partners, L.P. – 86,867

Deerfield International Master Fund, L.P. –
110,557

Deerfield Private Design Fund III, L.P. – 877,799

James E. Flynn – 1,224,899

Sole power to dispose or to direct the disposition of

Shared power to dispose or to direct the disposition
of

Deerfield Mgmt, L.P. – 347,100

Deerfield Mgmt III, L.P. – 877,799

Deerfield Management Company, L.P. –
1,224,899

Deerfield Special Situations Fund, L.P.
– 149,676

Deerfield Partners, L.P. – 86,867

Deerfield International Master Fund,
L.P. – 110,557

Deerfield Private Design Fund III, L.P.
– 877,799

James E. Flynn – 1,224,899