13G Filing: James E. Flynn and Ardelyx Inc. (ARDX)

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Page 9 of 14 – SEC Filing

CUSIP No. 039697107 13G Page 9
of 11 Pages
(j) A non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J);
(k) Group, in accordance with Rule 13d-1(b)(1)(ii)(K).

If filing as a non-U.S. institution in accordance
with Rule 13d-1(b)(1)(ii)(J), please specify the type of institution: _________________

Item 4. Ownership.

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a) Amount beneficially owned**:

Deerfield Mgmt, L.P. – 2,746,480 shares

Deerfield Management Company, L.P. – 2,746,480 shares

Deerfield Special Situations Fund, L.P. – 402,832
shares

Deerfield Partners, L.P. – 1,382,752 shares

Deerfield International Master Fund, L.P. – 960,896
shares

James E. Flynn – 2,746,480 shares

(b) Percent of class**:

Deerfield Mgmt, L.P. – 5.79%

Deerfield Management Company, L.P. – 5.79%

Deerfield Special Situations Fund, L.P. –
0.85%

Deerfield Partners, L.P. – 2.91%

Deerfield International Master Fund, L.P. –
2.03%

James E. Flynn – 5.79%

(c) Number of shares as to which such person has**:
(i) Sole power to vote or to direct the vote: All Reporting Persons 0
(ii) Shared power to vote or to direct the vote:

Deerfield
Mgmt, L.P. – 2,746,480

Deerfield
Management Company, L.P. – 2,746,480

Deerfield
Special Situations Fund, L.P. – 402,832

Deerfield
Partners, L.P. – 1,382,752

Deerfield
International Master Fund, L.P. – 960,896

James
E. Flynn – 2,746,480

(iii)

Sole power to dispose or to direct the disposition of:

All Reporting Persons – 0
(iv)

Shared power to dispose or to direct the disposition
of:

Deerfield
Mgmt, L.P. – 2,746,480

Deerfield
Management Company, L.P. – 2,746,480

Deerfield
Special Situations Fund, L.P. – 402,832

Deerfield
Partners, L.P. – 1,382,752

Deerfield
International Master Fund, L.P. – 960,896

James
E. Flynn – 2,746,480

**See footnotes on cover pages which are incorporated by reference
herein.

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