13G Filing: D E Shaw and Ophthotech Corp. (OPHT)

One Penn Plaza, 19th Floor

New York, NY 10119

D. E. Shaw & Co., L.P.

David E. Shaw

The business address for each reporting person is:

1166 Avenue of the Americas, 9^th Floor

New York, NY 10036

D. E. Shaw & Co., L.P. is a limited partnership organized
under the laws of the state of Delaware.

David E. Shaw is a citizen of the United States of America.

If this statement is filed pursuant to Rule 13d-1(b) or 13d-2(b)
or (c), check whether the person filing is a:

Not Applicable

Ownership

D. E. Shaw & Co., L.P.:

1,805,361 shares

This is composed of (i) 955,734 shares in the name of D. E. Shaw
Valence Portfolios, L.L.C., (ii) 340,896 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (iii) 200 shares
in the name of D. E. Shaw Heliant Capital, L.L.C., (iv) 33 shares in the name of D. E. Shaw Asymptote Portfolios, L.L.C., and (v)
508,498 shares under the management of D. E. Shaw Investment Management, L.L.C.

David E. Shaw:

1,805,361 shares

This is composed of (i) 955,734 shares in the name
of D. E. Shaw Valence Portfolios, L.L.C., (ii) 340,896 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (iii) 200 shares
in the name of D. E. Shaw Heliant Capital, L.L.C., (iv) 33 shares in the name of D. E. Shaw Asymptote Portfolios, L.L.C., and
(v) 508,498 shares under the management of D. E. Shaw Investment Management, L.L.C.