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Ownership Summary Table
| Name | Sole Voting Power | Shared Voting Power | Sole Dispositive Power | Shared Dispositive Power | Aggregate Amount Owned Power | Percent of Class |
|---|---|---|---|---|---|---|
| Cormorant Global Healthcare Master Fund | 0 | 1,450,825 | 0 | 1,450,825 | 1,450,825 | 7.6% |
| Cormorant Global Healthcare GP | 0 | 1,450,825 | 0 | 1,450,825 | 1,450,825 | 7.6% |
| Cormorant Asset Management | 0 | 1,725,460 | 0 | 1,725,460 | 1,725,460 | 9.0% |
| Bihua Chen | 0 | 1,725,460 | 0 | 1,725,460 | 1,725,460 | 9.0% |
Page 1 of 8 SEC Filing
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 | OMB APPROVAL | |
| OMB Number:3235-0145 Expires: February 28, 2009 Estimated average burden hours per response… 10.4 | ||
| SCHEDULE 13G | ||
| Under the Securities Exchange Act of 1934 | ||
| (Amendment No. ___)* |
| Proteostasis Therapeutics, Inc. | ||
| (Name of Issuer) |
| Common Stock, par value $0.001 per share | ||
| (Title of Class of Securities) |
| 74373B109 | ||
| (CUSIP Number) |
| February 16, 2016 | ||
| (Date of Event which Requires Filing of this Statement) |
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
[ ] Rule 13d-1(b)
[x] Rule 13d-1(c)
[ ] Rule 13d-1(d)
___________________________________
* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
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Page 2 of 8 SEC Filing
| 1 | Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) Cormorant Global Healthcare Master Fund, LP | ||
| 2 | Check the Appropriate Box if a Member of a Group (See Instructions) | ||
| (a) [ ] | |||
| (b) [x] | |||
| 3 | SEC Use Only | ||
| 4 | Citizenship or Place of Organization. Cayman Islands | ||
| Number of Shares Beneficially Owned by Each Reporting Person With | 5 Sole Voting Power 0 shares | ||
| 6 Shared Voting Power 1,450,825 shares (1,466,734 shares as of February 26, 2016) Refer to Item 4 below. | |||
| 7 Sole Dispositive Power 0 shares | |||
| 8 Shared Dispositive Power 1,450,825 shares (1,466,734 shares as of February 26, 2016) Refer to Item 4 below. | |||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person 1,450,825 shares (1,466,734 shares as of February 26, 2016) Refer to Item 4 below. | ||
| 10 | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] N/A | ||
| 11 | Percent of Class Represented by Amount in Row (9)* 7.6% (7.7% as of February 26, 2016) Refer to Item 4 below. | ||
| 12 | Type of Reporting Person (See Instructions) PN (Partnership) | ||
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Page 3 of 8 SEC Filing
| 1 | Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) Cormorant Global Healthcare GP, LLC | ||
| 2 | Check the Appropriate Box if a Member of a Group (See Instructions) | ||
| (a) [ ] | |||
| (b) [x] | |||
| 3 | SEC Use Only | ||
| 4 | Citizenship or Place of Organization. Delaware | ||
| Number of Shares Beneficially Owned by Each Reporting Person With | 5 Sole Voting Power 0 shares | ||
| 6 Shared Voting Power 1,450,825 shares (1,466,734 shares as of February 26, 2016) Refer to Item 4 below. | |||
| 7 Sole Dispositive Power 0 shares | |||
| 8 Shared Dispositive Power 1,450,825 shares (1,466,734 shares as of February 26, 2016) Refer to Item 4 below. | |||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person 1,450,825 shares (1,466,734 shares as of February 26, 2016) Refer to Item 4 below. | ||
| 10 | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] N/A | ||
| 11 | Percent of Class Represented by Amount in Row (9)* 7.6% (7.7% as of February 26, 2016) Refer to Item 4 below. | ||
| 12 | Type of Reporting Person (See Instructions) OO (Limited Liability Company) | ||
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Page 4 of 8 SEC Filing
| 1 | Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) Cormorant Asset Management, LLC | ||
| 2 | Check the Appropriate Box if a Member of a Group (See Instructions) | ||
| (a) [ ] | |||
| (b) [x] | |||
| 3 | SEC Use Only | ||
| 4 | Citizenship or Place of Organization. Delaware | ||
| Number of Shares Beneficially Owned by Each Reporting Person With | 5 Sole Voting Power 0 shares | ||
| 6 Shared Voting Power 1,725,460 shares (1,744,399 shares as of February 26, 2016) Refer to Item 4 below. | |||
| 7 Sole Dispositive Power 0 shares | |||
| 8 Shared Dispositive Power 1,725,460 shares (1,744,399 shares as of February 26, 2016) Refer to Item 4 below. | |||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person 1,725,460 shares (1,744,399 shares as of February 26, 2016) Refer to Item 4 below. | ||
| 10 | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] N/A | ||
| 11 | Percent of Class Represented by Amount in Row (9)* 9.0% (9.1% as of February 26, 2016) Refer to Item 4 below. | ||
| 12 | Type of Reporting Person (See Instructions) OO (Limited Liability Company) | ||
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Page 5 of 8 SEC Filing
| 1 | Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only) Bihua Chen | ||
| 2 | Check the Appropriate Box if a Member of a Group (See Instructions) | ||
| (a) [ ] | |||
| (b) [x] | |||
| 3 | SEC Use Only | ||
| 4 | Citizenship or Place of Organization. United States | ||
| Number of Shares Beneficially Owned by Each Reporting Person With | 5 Sole Voting Power 0 shares | ||
| 6 Shared Voting Power 1,725,460 shares (1,744,399 shares as of February 26, 2016) Refer to Item 4 below. | |||
| 7 Sole Dispositive Power 0 shares | |||
| 8 Shared Dispositive Power 1,725,460 shares (1,744,399 shares as of February 26, 2016) Refer to Item 4 below. | |||
| 9 | Aggregate Amount Beneficially Owned by Each Reporting Person 1,725,460 shares (1,744,399 shares as of February 26, 2016) Refer to Item 4 below. | ||
| 10 | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) [ ] N/A | ||
| 11 | Percent of Class Represented by Amount in Row (9)* 9.0% (9.1% as of February 26, 2016) Refer to Item 4 below. | ||
| 12 | Type of Reporting Person (See Instructions) IN (Individual) | ||
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Page 6 of 8 SEC Filing
Item 1.
| (a) | Name of Issuer |
| Proteostasis Therapeutics, Inc. | |
| (b) | Address of Issuer’s Principal Executive Offices |
| 200 Technology Square, 4th Floor Cambridge, Massachusetts 02139 |
Item 2.
| (a) | Name of Person Filing |
| Cormorant Global Healthcare Master Fund, LP Cormorant Global Healthcare GP, LLC Cormorant Asset Management, LLC Bihua Chen | |
| (b) | Address of Principal Business Office or, if none, Residence |
| 200 Clarendon Street, 52nd Floor Boston, MA 02116 | |
| (c) | Citizenship |
| Cormorant Global Healthcare Master Fund, LP – Cayman Islands Cormorant Global Healthcare GP, LLC – Delaware Cormorant Asset Management, LLC – Delaware Bihua Chen – United States | |
| (d) | Title of Class of Securities |
| Common Stock | |
| (e) | CUSIP Number |
| 74373B109 |
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Page 7 of 8 SEC Filing
| Item 3. | If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a: |
| (a) | [ ] | Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o). |
| (b) | [ ] | Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c). |
| (c) | [ ] | Insurance Company as defined in Section 3(a)(19) of the Act |
| (d) | [ ] | Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8). |
| (e) | [ ] | An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E); |
| (f) | [ ] | An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F); |
| (g) | [ ] | A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G); |
| (h) | [ ] | A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813); |
| (i) | [ ] | A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3); |
| (j) | [ ] | A non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J); |
| (k) | [ ] | Group, in accordance with §240.13d-1(b)(1)(ii)(K). |
| Item 4. | Ownership*** |
Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.
| (a) | Amount Beneficially Owned*** | |
| Cormorant Global Healthcare Master Fund, LP – 1,450,825 shares (1,466,734 shares as of February 26, 2016) Cormorant Global Healthcare GP, LLC – 1,450,825 shares (1,466,734 shares as of February 26, 2016) Cormorant Asset Management, LLC – 1,725,460 shares (1,744,399 shares as of February 26, 2016) Bihua Chen – 1,725,460 shares (1,744,399 shares as of February 26, 2016) | ||
| (b) | Percent of Class | |
| Cormorant Global Healthcare Master Fund, LP – 7.6% (7.7% as of February 26, 2016) Cormorant Global Healthcare GP, LLC – 7.6% (7.7% as of February 26, 2016) Cormorant Asset Management, LLC – 9.0% (9.1% as of February 26, 2016) Bihua Chen – 9.0% (9.1% as of February 26, 2016) | ||
| (c) | Number of shares as to which such person has: | |
| (i) | sole power to vote or to direct the vote | |
| Cormorant Global Healthcare Master Fund, LP – 0 shares Cormorant Global Healthcare GP, LLC – 0 shares Cormorant Asset Management, LLC – 0 shares Bihua Chen – 0 shares | ||
| (ii) | shared power to vote or to direct the vote | |
| Cormorant Global Healthcare Master Fund, LP – 1,450,825 shares (1,466,734 shares as of February 26, 2016) Cormorant Global Healthcare GP, LLC – 1,450,825 shares (1,466,734 shares as of February 26, 2016) Cormorant Asset Management, LLC – 1,725,460 shares (1,744,399 shares as of February 26, 2016) Bihua Chen – 1,725,460 shares (1,744,399 shares as of February 26, 2016) | ||
| (iii) | sole power to dispose or to direct the disposition of | |
| Cormorant Global Healthcare Master Fund, LP – 1,450,825 shares (1,466,734 shares as of February 26, 2016) Cormorant Global Healthcare GP, LLC – 1,450,825 shares (1,466,734 shares as of February 26, 2016) Cormorant Asset Management, LLC – 1,725,460 shares (1,744,399 shares as of February 26, 2016) Bihua Chen – 1,725,460 shares (1,744,399 shares as of February 26, 2016) | ||
| (iv) | shared power to dispose or to direct the disposition of | |
| Cormorant Global Healthcare Master Fund, LP – 1,450,825 shares (1,466,734 shares as of February 26, 2016) Cormorant Global Healthcare GP, LLC – 1,450,825 shares (1,466,734 shares as of February 26, 2016) Cormorant Asset Management, LLC – 1,725,460 shares (1,744,399 shares as of February 26, 2016) Bihua Chen – 1,725,460 shares (1,744,399 shares as of February 26, 2016) | ||
*** Shares reported herein for Cormorant Asset Management, LLC represent shares which are beneficially owned by Cormorant Global Healthcare Master Fund, LP (the “Fund”), as reported herein, and shares which are beneficially owned by a managed account (the “Account”). Cormorant Global Healthcare GP, LLC serves as the general partner of the Fund, and Cormorant Asset Management, LLC serves as the investment manager to both the Fund and the Account. Bihua Chen serves as the managing member of Cormorant Global Healthcare GP, LLC and Cormorant Asset Management, LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or his pecuniary interest therein.
| Item 5. | Ownership of Five Percent or Less of a Class |
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [ ].
| Item 6. | Ownership of More than Five Percent on Behalf of Another Person |
Not applicable.
| Item 7. | Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company |
Not applicable.
| Item 8. | Identification and Classification of Members of the Group |
Not applicable.
| Item 9. | Notice of Dissolution of Group |
Not applicable.
| Item 10. | Certification |
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.
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Page 8 of 8 SEC Filing
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this Statement is true, complete and correct.
February 26, 2016
CORMORANT GLOBAL HEALTHCARE MASTER FUND, LP
By: Cormorant Global Healthcare GP, LLC
its General Partner
By: /s/ Bihua Chen
Bihua Chen, Managing Member
CORMORANT GLOBAL HEALTHCARE GP, LLC
By: /s/ Bihua Chen
Bihua Chen, Managing Member
CORMORANT ASSET MANAGEMENT, LLC
By: /s/ Bihua Chen
Bihua Chen, Managing Member
/s/ Bihua Chen
Bihua Chen
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