	/x/	Not applicable.

(a)	/ /	Broker or dealer registered under Section 15 of the Exchange Act.

(b)	/ /	Bank as defined in Section 3(a)(6) of the Exchange Act.

(c)	/ /	Insurance company as defined in Section 3(a)(19) of the Exchange Act.

(d)	/ /	Investment company registered under Section 8 of the Investment Company Act.

(e)	/ /	An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).

(f)	/ /	An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F).

(g)	/ /	A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G).

(h)	/ /	A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act.

(i)	/ /	A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act.

(j)	/ /	Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

(k)	/ /	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with Rule 240.13d-1(b)(1)(ii)(J), please specify the type of institution: ____

Item 4.

Ownership

(a)

Amount beneficially owned:

As of the close of business on May
5, 2017 (i) BVF beneficially owned 1,507,731 shares of Common Stock, (ii) BVF2 beneficially owned 987,526 shares of Common Stock,
and (iii) Trading Fund OS beneficially owned 272,433 shares of Common Stock.

Partners OS, as the general partner
of Trading Fund OS may be deemed to beneficially own the 272,433 shares of Common Stock beneficially owned by Trading Fund OS.

Partners, as the general partner of
BVF, BVF2, the investment manager of Trading Fund OS, and the sole member of Partners OS, may be deemed to beneficially own the
3,278,900 shares of Common Stock beneficially owned in the aggregate by BVF, BVF2, Trading Fund OS, and certain Partners managed
accounts (the “Partners Managed Accounts”), including 511,210 shares of Common Stock held in the Partners Managed Accounts.

10

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NASDAQ:RGLS SEC 13G Filing Biotechnology Value Fund L P Regulus Therapeutics Inc. (RGLS)

13G Filing: Biotechnology Value Fund LP and Regulus Therapeutics Inc. (RGLS)

Published on May 8, 2017 at 2:03 pm by Insider Monkey Staff in Hedge Funds

Page 10 of 13 – SEC Filing

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