Page 8 of 13 – SEC Filing
| (c) | The Reporting Persons have engaged in the following transactions in the Issuer’s Common Stock during the last 60 days: |
| Entity | Transaction | Trade Date | Shares | Price/ Share |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 11/6/2017 | 2,813 | $1.20 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 11/7/2017 | 16,033 | $1.17 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 11/9/2017 | 4,064 | $1.01 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Sale | 11/14/2017 | 51,911 | $1.59 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 11/14/2017 | 11,133 | $1.24 |
| Sabby Volatility Warrant Master Fund, Ltd. | Open Market Sale | 11/14/2017 | 6,200 | $1.67 |
| Sabby Volatility Warrant Master Fund, Ltd. | Open Market Purchase | 11/14/2017 | 7,450 | $1.25 |
| Sabby Volatility Warrant Master Fund, Ltd. | Open Market Sale | 11/14/2017 | 13,020 | $1.63 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 11/15/2017 | 700 | $1.25 |
| Sabby Volatility Warrant Master Fund, Ltd. | Open Market Purchase | 11/15/2017 | 200 | $1.25 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Sale | 11/16/2017 | 16,733 | $1.50 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Sale | 11/16/2017 | 105 | $1.51 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Sale | 11/17/2017 | 5,566 | $1.49 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Sale | 11/30/2017 | 300 | $1.48 |
| Sabby Volatility Warrant Master Fund, Ltd. | Open Market Purchase | 11/30/2017 | 8,930 | $1.33 |
| Sabby Volatility Warrant Master Fund, Ltd. | Open Market Purchase | 12/1/2017 | 2,640 | $1.33 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/4/2017 | 3,998 | $1.26 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/5/2017 | 4,904 | $1.25 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/6/2017 | 600 | $1.25 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/7/2017 | 13,257 | $1.22 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/8/2017 | 4,423 | $1.20 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/8/2017 | 11,743 | $1.20 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/11/2017 | 4,132 | $1.21 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/13/2017 | 4,368 | $1.21 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/14/2017 | 5,800 | $1.19 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/15/2017 | 2,028 | $1.21 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Sale | 12/18/2017 | 3,600 | $1.38 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Sale | 12/18/2017 | 5,700 | $1.37 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/19/2017 | 20,000 | $1.21 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/21/2017 | 19,227 | $1.18 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/22/2017 | 5,773 | $1.20 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/26/2017 | 6,321 | $1.17 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/26/2017 | 3,263 | $1.19 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/26/2017 | 8,795 | $1.18 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/27/2017 | 9,988 | $1.20 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/27/2017 | 1,200 | $1.20 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/27/2017 | 648 | $1.20 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/28/2017 | 4,084 | $1.23 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/28/2017 | 2,210 | $1.20 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/29/2017 | 16,067 | $1.23 |
| Sabby Healthcare Master Fund, Ltd. | Open Market Purchase | 12/29/2017 | 100 | $1.20 |
| (d) | Not applicable. |
| (e) | Not applicable. |
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