Page 5 of 8 – SEC Filing
The following constitutes
the Schedule 13D filed by the undersigned (the “Schedule 13D”).
| Item 1. | Security and Issuer. |
This statement relates
to the common stock, par value $0.01 per share (the “Shares”), of BioCryst Pharmaceuticals, Inc. (the “Issuer”).
The address of the principal executive offices of the Issuer is 4505 Emperor Blvd., Suite 200, Durham, North Carolina 27703.
| Item 2. | Identity and Background. |
(a) This Schedule
13D is being filed on behalf of (i) RA Capital Management, LLC (“RA Capital”), (ii) Peter Kolchinsky, and (iii) RA
Capital Healthcare Fund, L.P. (the “Fund” and, together with each of the foregoing, the “Reporting Persons”).
The Shares reported
herein for RA Capital represent Shares reported for the Fund as well as Shares held in a separately managed account (the “Account”).
RA Capital is the general partner of the Fund, which owns 4,964,818 Shares, and serves as investment adviser for the Account,
which owns 2,019,874 Shares. Peter Kolchinsky is the manager of RA Capital. As the investment adviser to the Fund and the Account,
RA Capital may be deemed a beneficial owner, for purposes of Section 13(d) of the Securities Exchange Act of 1934 (the “Act”),
of any securities of the Issuer owned by the Fund or the Account. As the manager of RA Capital, Mr. Kolchinsky may be deemed a
beneficial owner, for purposes of Section 13(d) of the Act, of any securities of the Issuer beneficially owned by RA Capital.
RA Capital and Mr. Kolchinsky disclaim beneficial ownership of the securities reported in this Schedule 13D Statement (the “Statement”)
other than for the purpose of determining their obligations under Section 13(d) of the Act, and neither the filing of the Statement
nor the filing of this Amendment shall be deemed an admission that either RA Capital or Mr. Kolchinsky is or was the beneficial
owner of such securities for any other purpose.
(b) The business
address of each of the Reporting Persons is: 20 Park Plaza, Suite 1200, Boston, MA 02116.
(c) The Fund
is a private investment vehicle. RA Capital is a registered investment adviser and provides investment management services to the
Fund and the Account. The principal occupation of Mr. Kolchinsky is investment management.
(d) None of the
Reporting Persons has, during the last five years, been convicted in a criminal proceeding (excluding traffic violations or similar
misdemeanors).
(e) None of the
Reporting Persons has, during the last five years, been a party to a civil proceeding of a judicial or administrative body of competent
jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations
of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to
such laws.
(f) See Item
6 of the cover pages.
| Item 3. | Source and Amount of Funds or Other Consideration. |
The Reporting Persons
acquired the Shares with working capital (which may, at any given time, include margin loans made by brokerage firms in the ordinary
course of business). The aggregate purchase price of the 6,984,692 Shares beneficially owned by the Reporting Persons is approximately
$43,978,918, including applicable brokerage commissions.
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