13D Filing: James E. Flynn and Proteon Therapeutics Inc (PRTO)

Page 14 of 21

(2) Deerfield Mgmt

Sole power to vote or direct the
vote: 0

Shared power to vote or direct
the vote: 347,100

Sole power to dispose or to direct
the disposition: 0

Shared power to dispose or direct
the disposition: 347,100

(4) Deerfield Mgmt III

Sole power to vote or direct the
vote: 0

Shared power to vote or direct
the vote: 877,799

Sole power to dispose or to direct
the disposition: 0

Shared power to dispose or direct
the disposition: 877,799

(4) Deerfield Partners

Sole power to vote or direct the
vote: 0

Shared power to vote or direct
the vote: 86,867

Sole power to dispose or to direct
the disposition: 0

Shared power to dispose or direct
the disposition: 86,867

(5) Deerfield Special Situations
Fund

Sole power to vote or direct the
vote: 0

Shared power to vote or direct
the vote: 149,676

Sole power to dispose or to direct
the disposition: 0

Shared power to dispose or direct
the disposition: 149,676

(6) Deerfield International Master
Fund

Sole power to vote or direct the
vote: 0

Shared power to vote or direct
the vote: 110,557

Sole power to dispose or to direct
the disposition: 0

Shared power to dispose or direct
the disposition: 110,557

(7) Deerfield Private Design
Fund III

Sole power to vote or direct the
vote: 0

Shared power to vote or direct
the vote: 877,799

Sole power to dispose or to direct
the disposition: 0

Shared power
to dispose or direct the disposition: 877,799

(8) Deerfield Private Design
Fund IV

Sole power to vote or direct the
vote: 0

Shared power to vote or direct
the vote: 16,082,018

Sole power to dispose or to direct
the disposition: 0

Shared power
to dispose or direct the disposition: 16,082,018