13D Filing: James E. Flynn and Homology Medicines Inc (FIXX)

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Page 10 of 20 – SEC Filing

CUSIP No.  438083107 Page 10 of 18 Pages

This Schedule 13D is filed by (i) Deerfield
Mgmt III, L.P. (“Deerfield Mgmt III”), (ii) Deerfield Private Design Fund III, L.P. (“Deerfield Private
Design Fund III
”), (iii) Deerfield Mgmt, L.P. (“Deerfield Mgmt”), (iv) Deerfield Partners, L.P. (“Deerfield
Partners
”), (v) Deerfield Healthcare Innovations Fund, L.P. (“Deerfield Healthcare Innovations Fund”),
(vi) Deerfield Mgmt HIF, L.P. (“Deerfield Mgmt HIF”), (vii) Deerfield Management Company, L.P. (“Deerfield
Management
”) and (viii) James E. Flynn, a natural person (“Flynn” and collectively with Deerfield
Mgmt III, Deerfield Private Design Fund III, Deerfield Mgmt, Deerfield Partners, Deerfield Healthcare Innovations Fund, Deerfield
Mgmt HIF and Deerfield Management, the “Reporting Persons”), with respect to the common stock of Homology Medicines,
Inc. Deerfield Private Design Fund III, Deerfield Partners and Deerfield Healthcare Innovations Fund are collectively referred
to herein as the “Funds”).

Item 1. Security and Issuer.

This Statement on Schedule 13D relates to the shares of common
stock, par value $0.0001 per share (the “Common Stock”), of Homology Medicines, Inc., a Delaware corporation
(the “Company”). The address of the Company’s principal executive offices is 45 Wiggins Avenue, Bedford, Massachusetts
01730.

Item 2. Identity and Background.
(a) This Statement is filed as a joint statement pursuant to Rule 13d-1(k) promulgated under the Securities
Exchange Act of 1934 (the “Exchange Act”) by the Reporting Persons.
(b) The address of the principal business and/or principal office of the Reporting Persons is 780 Third
Avenue, 37th Floor, New York, New York 10017.
(c) Flynn is the managing member of the general partner of each of Deerfield Mgmt, Deerfield Mgmt III,
Deerfield Mgmt HIF and Deerfield Management.   Deerfield Mgmt III is the general partner of Deerfield Private Design
Fund III; Deerfield Mgmt is the general partner of Deerfield Partners; and Deerfield Mgmt HIF is the general partner of Deerfield
Healthcare Innovations Fund and Deerfield Management is the investment manager of the Funds. The Funds purchase, hold and sell
securities and other investment products. Schedule A hereto sets forth information regarding persons referred in Instruction
C to Schedule 13D.
(d) During the last five
years, none of the Reporting Persons, nor, to the best of each of the Reporting Person’s
knowledge, any of the persons listed on Schedule A attached hereto, has been convicted
in a criminal proceeding (excluding traffic violations or similar misdemeanors).
(e) In September 2013, Deerfield Management voluntarily agreed to settle a Securities and Exchange
Commission (“SEC”) inquiry relating to six alleged violations of Rule 105 of Regulation M under the Securities
Exchange Act of 1934, as amended, without admitting or denying the SEC’s allegations. The violations allegedly occurred between
December 2010 and January 2013. Rule 105 generally prohibits purchasing an equity security in a registered offering if the purchaser
sold short the same security during a restricted period (generally defined as five business days before the pricing of the offering).
Rule 105’s prohibition applies irrespective of any intent to violate the rule. The settlement involved the payment by Deerfield
Management of disgorgement, prejudgment interest and a civil money penalty in the aggregate amount of $1,902,224.

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