13D Filing: James E. Flynn and DFB Healthcare Acquisitions Corp.

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE
13D

[Rule 13d-101]

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO §
24.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13D-2(a)

(Amendment No. 1)*

DFB
Healthcare Acquisitions Corp.

(Name
of Issuer)

Common
Stock, par value $0.0001 per share

(Title
of Class of Securities)

23291E208

(CUSIP
Number)

(Name,
Address and Telephone Number of Person Authorized to Receive Notices and Communications)

April
2, 2018

(Date
of Event which Requires Filing of this Statement)

If the filing person
has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing
this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box ☐.

Note: Schedules
filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See § 240.13d-7
for other parties to whom copies are to be sent.

(Continued on following
pages)
(Page 1 of 10 Pages)

* The remainder of this cover page shall be filled out for a
reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page
shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).

SCHEDULE 13D

(1) Comprised of 2,500,000 shares held by Deerfield Private
Design Fund IV, L.P. and 6,045,652 shares held by Deerfield/RAB Ventures, LLC.

(2) Does not include 833,333 shares of common stock issuable
upon exercise of warrants held by Deerfield Private Design Fund IV, L.P. and 4,333,333 shares of common stock issuable upon exercise
of warrants held by Deerfield/RAB Ventures, LLC, which are not presently exercisable and are not exercisable within 60 days from
the date hereof.

SCHEDULE 13D

(3) Comprised of 2,500,000 shares held by Deerfield Private
Design Fund IV, L.P. and 6,045,652 shares held by Deerfield/RAB Ventures, LLC.

(4) Does not include 833,333 shares of common stock issuable
upon exercise of warrants held by Deerfield Private Design Fund IV, L.P. and 4,333,333 shares of common stock issuable upon exercise
of warrants held by Deerfield/RAB Ventures, LLC, which are not presently exercisable and are not exercisable within 60 days from
the date hereof.

SCHEDULE 13D

(5) Comprised of 2,500,000 shares held by Deerfield Private
Design Fund IV, L.P., 6,045,652 shares held by Deerfield/RAB Ventures, LLC and 26,087 shares held by Steven Hochberg, an employee
of Deerfield Management Company and a member of the Issuer’s board of directors, for the benefit, and subject to the direction,
of Deerfield Management Company.

(6) Does not include 833,333 shares of common stock issuable
upon exercise of warrants held by Deerfield Private Design Fund IV, L.P. and 4,333,333 shares of common stock issuable upon exercise
of warrants held by Deerfield/RAB Ventures, LLC, which are not presently exercisable and are not exercisable within 60 days from
the date hereof.

SCHEDULE 13D

(7) Comprised of 2,500,000 shares held by Deerfield Private
Design Fund IV, L.P., 6,045,652 shares held by Deerfield/RAB Ventures, LLC and 26,087 shares held by Steven Hochberg, an employee
of Deerfield Management Company and a member of the Issuer’s board of directors, for the benefit, and subject to the direction,
of Deerfield Management Company.

(8) Does not include 833,333 shares of common stock issuable
upon exercise of warrants held by Deerfield Private Design Fund IV, L.P. and 4,333,333 shares of common stock issuable upon exercise
of warrants held by Deerfield/RAB Ventures, LLC, which are not presently exercisable and are not exercisable within 60 days from
the date hereof.

SCHEDULE 13D

(9) Comprised of shares held by Deerfield/RAB Ventures, LLC.

This Amendment No. 1 (this “Amendment”) to
Schedule 13D amends the Schedule 13D (“Schedule 13D”) filed by (i) Deerfield Mgmt IV, L.P. (“Deerfield
Mgmt IV”), (ii) Deerfield Private Design Fund IV, L.P. (“Deerfield Private Design Fund IV”), (iii)
Deerfield Management Company, L.P. (“Deerfield Management”), (iv) James E. Flynn, a natural person (“Flynn”),
and (v) Steven I. Hochberg, a natural person (“Hochberg” and collectively with Deerfield Mgmt IV, Deerfield
Private Design Fund IV, Deerfield Management and Flynn, the “Reporting Persons”), with respect to shares of
common stock, par value $0.0001 per share (the “Common Stock”) of DFB Healthcare Acquisitions Corp (the “Company”).
Capitalized terms used but not otherwise defined in this Amendment have the meanings ascribed to them in the Schedule 13D.

Item
4. Purpose of Transaction.

Pursuant to the Letter Agreement, up to 921,848 and 3,913 of
the Founder Shares held by the Sponsor and Hochberg, respectively, were subject to forfeiture depending upon the extent to which
the Underwriters exercised their over-allotment option in connection with the IPO. The Underwriters’ over-allotment option
expired unexercised on April 2, 2018 and, accordingly, the Sponsor and Hochberg subsequently forfeited, for no consideration, 921,848
and 3,913 Founder Shares, respectively.

Item 5. Interest in Securities of the Issuer.

Items 5(a), (b) and (c) of the Schedule 13D are hereby amended
and restated in their entirety as follows:

(a)

(1)      Deerfield
Mgmt IV

Number
of shares:  8,545,652 (comprised of shares held by Deerfield Private Design Fund IV and the Sponsor)

Percentage of shares: 27.35%

(2)      Deerfield
Management

Percentage of shares: 27.43%

(3)      Deerfield
Private Design Fund IV

Number
of shares:  8,545,652 (comprised of shares held directly and by the Sponsor)

Percentage of shares: 27.35%

(4)      Flynn

Percentage of shares: 27.43%

(5)      Hochberg

Number
of shares:  6,045,652 (comprised of shares held by the Sponsor)

Percentage of shares: 19.35%

(b)

(1)      Deerfield
Mgmt IV

Sole power to vote or direct the vote:
0

Shared power to vote or direct the vote:
8,545,652

Sole power to dispose or to direct the
disposition: 0

Shared power to dispose or direct the disposition: 8,545,652

(2)      Deerfield
Management

Sole power to vote or direct the vote:
0

Shared power to vote or direct the vote:
8,571,739

Sole power to dispose or to direct the
disposition: 0

Shared power to dispose or direct the disposition: 8,571,739

(3)      Deerfield Private Design Fund IV

Sole power to vote or direct the vote:
0

Shared power to vote or direct the vote:
8,545,652

Sole power to dispose or to direct the
disposition: 0

Shared power to dispose or direct the disposition: 8,545,652

(4)      Flynn

Sole power to vote or direct the vote:
0

Shared power to vote or direct the vote:
8,571,739

Sole power to dispose or to direct the
disposition: 0

Shared power to dispose or direct the disposition: 8,571,739

(4)      Hochberg

Sole power to vote or direct the vote:
0

Shared power to vote or direct the vote:
6,045,652

Sole power to dispose or to direct the
disposition: 0

Shared power to dispose or direct the disposition: 6,045,652

Flynn is the sole member of the general
partner of each of Deerfield Mgmt IV and Deerfield Management. Deerfield Mgmt IV is the general partner, and Deerfield Management
is the investment manager, of Deerfield Private Design Fund IV. Hochberg, an employee of Deerfield Management and a director of
the Company, also serves as Deerfield Private Design Fund IV’s designee on the board of managers of the Sponsor, which consists
of two managers.

Each Reporting Person may be deemed to
be a member of a “group” for purposes of the Securities Exchange Act of 1934 with the Sponsor and RAB Ventures (DFB)
LLC (“RAB”) (the other member of the Sponsor), and Richard Barasch. The Reporting Persons, the Sponsor, RAB and Mr.
Barasch may be deemed to collectively beneficially own an aggregate of 8,571,739 shares of Common Stock, or 27.43% of the issued
and outstanding shares of Common Stock. The share ownership reported for the Reporting Persons does not include any shares of Common
Stock held by the other member of the Sponsor or Mr. Barasch. Each Reporting Person disclaims beneficial ownership of any shares
of Common Stock beneficially owned by the other member of the Sponsor, except with respect to the shares owned by the Sponsor as
disclosed in this Schedule 13D.

(c) Except as set forth in Items 3 and
4 of this Schedule 13D, the Reporting Persons have not engaged in any transactions in the Company’s securities during the
past 60 days.

SIGNATURE

After reasonable inquiry
and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true,
complete and correct.

Dated: April 4, 2018