13D Filing: James E. Flynn and Alpine Immune Sciences Inc. (ALPN)

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Page 14 of 15 – SEC Filing

SIGNATURE

After reasonable inquiry
and to the best of their knowledge and belief, the undersigned certify that the information set forth in this statement is true,
complete and correct.


Dated: July 28, 2017

DEERFIELD MGMT, L.P.

By: J.E. Flynn Capital, LLC, General Partner

By: /s/ Jonathan
Isler

Name: Jonathan
Isler

Title: Attorney-in-Fact

DEERFIELD SPECIAL SITUATIONS FUND, L.P.

By: Deerfield Mgmt,
L.P., General Partner

By: J.E. Flynn Capital, LLC, General Partner

By: /s/ Jonathan
Isler

Name: Jonathan
Isler

Title: Attorney-in-Fact

DEERFIELD PRIVATE DESIGN FUND, L.P.

By: Deerfield Mgmt,
L.P., General Partner

By: J.E. Flynn Capital, LLC, General Partner

By: /s/ Jonathan
Isler

Name: Jonathan
Isler

Title: Attorney-in-Fact

DEERFIELD PRIVATE DESIGN INTERNATIONAL, L.P.

By: Deerfield Mgmt,
L.P., General Partner

By: J.E. Flynn Capital, LLC, General Partner

By: /s/ Jonathan
Isler

Name: Jonathan
Isler

Title: Attorney-in-Fact

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