13D Filing: James E. Flynn and Alpine Immune Sciences Inc. (ALPN)

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(2) Deerfield Management
Number of shares: 936,175 (comprised of shares held by Deerfield Special Situations International, Deerfield Special Situations Fund, Deerfield Private Design, Deerfield Private Design International, Deerfield Private Design II and Deerfield Private Design International II and shares underlying the September 2016 Option)
Percentage of shares: 6.74%
(3) Deerfield Special Situations Fund
Number of shares: 281,184
Percentage of shares: 2.03%
(4) Deerfield Private Design
Number of shares:  100,515
Percentage of shares: 0.72%
(5) Deerfield Private Design International
Number of Shares:  161,788
Percentage of Shares:  1.17%
(6) Deerfield Private Design II
Number of Shares:  181,560
Percentage of Shares:  1.31%
(7) Deerfield Private Design International II
Number of Shares:  208,053
Percentage of Shares:  1.50%
(8) Flynn
Number of shares: 936,175 (comprised of shares held by Deerfield Special Situations Fund, Deerfield Private Design, Deerfield Private Design International, Deerfield Private Design II and Deerfield Private Design International II and shares underlying the September 2016 Option)
Percentage of shares: 6.74%
(b)
(1) Deerfield Mgmt
Sole power to vote or direct the vote:  0
Shared power to vote or direct the vote:   933,100
Sole power to dispose or to direct the disposition:  0
Shared power to dispose or direct the disposition:   933,100

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