2. Quito, Ecuador
One of the cheapest destinations on our list of best places to visit in Central and South America in May, is Quito the Capital city of Ecuador. If you are thinking less than $10 per night, then Quito is where you will find it. On top of that, this Ecuadorian city has the best weather during the month of May although the city pretty much experiences great weather during the whole year as it sits 2,850 meters above the sea level.