9. Panama City, Panama
Average cost per night: $138
Next up on our list of best places to visit in Central and South America in April, we have the capital of Panama, Panama City. You can imagine this is going to be a busy city, as this is the capital of Panama. However, the main attraction of Panama City is that it is basically framed by the Pacific ocean. That means, there are long uninterrupted beaches lining the city’s exterior and you can partake in all sorts of beach activity in gorgeous weather during the month of April.