8. Oklahoma
Rate of Chlamydia per 100,000 people: 542.2
Rate of Gonorrhea per 100,000 people: 168.7
Rate of Syphilis per 100,000 people: 5.4
Insider Monkey Score: 2.67
Up next in our list of states with the highest STD rates in America is Oklahoma that has always had a problem with STDs, and hence it may be assumed, with safe sex. The concerning fact is that there has been a vast increase in first and second stage syphilis in the state from 2013 to 2015, with a 77% increase being noted in this time period.

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