5. The Binding of Isaac
Units Sold: 2.5 million
Metacritic Score: 84
Another roguelike, The Binding of Isaac is inspired by biblical themes and stories. In the game, you play Isaac, who must fight to survive the monster-filled basement after he tries to run away from his religiously delusional mother. The game features a lot of unlockable content and multiple combinations of items can be made. The success of this game prompted a remake which was released in 2014. And now, let’s see the top four entries in our list of most successful indie games of all time.
