11 Most Promising Small-Cap Stocks According to Analysts

3. Structure Therapeutics Inc. (NASDAQ:GPCR)

Market Capitalization as of April 23: $1.34 billion

Number of Hedge Fund Holders: 40

Average Upside Potential as of April 23: 239.27%

Structure Therapeutics Inc. (NASDAQ:GPCR) develops and delivers oral small-molecule therapeutics to treat various chronic diseases with unmet medical needs in the US. Its lead product candidate is GSBR-1290 (Aleniglipron), which is an oral and biased small-molecule agonist of the GLP-1 receptor. It’s in two-phase 2 clinical trials for the treatment of obesity and related conditions.

The company’s Aleniglipron program is central to its strategy in the obesity market. As of February, enrollment is fully completed in both the ACCESS study (~220 adults) and the ACCESS II study (~80 adults), which totals over 300 patients. These studies are evaluating different dose levels (up to 120 mg in ACCESS and higher doses of 180 mg and 240 mg in ACCESS II) with optimized 4-week titration regimens. Topline 36-week data from both ACCESS and ACCESS II are anticipated by year-end 2025.

Positive data from these studies would position aleniglipron as a potentially best-in-class oral GLP-1 small molecule, with the advantage of being combinable with other medicines. With 36-week data expected by the end of 2025, this program is the most advanced in Structure Therapeutics Inc.’s (NASDAQ:GPCR) portfolio and is expected to influence the company’s overall growth trajectory.